Vrachatis Dimitrios A, Papathanasiou Konstantinos A, Giotaki Sotiria G, Iliodromitis Konstantinos E, Papaioannou Theodore G, Stefanini Giulio G, Cleman Michael, Siasos Gerasimos, Reimers Bernhard, Lansky Alexandra, Tardif Jean-Claude, Deftereos Spyridon G, Giannopoulos George
2nd Department of Cardiology, National and Kapodistrian University of Athens, Athens, Greece.
Evangelisches Krankenhaus Hagen-Haspe, Clinic for Cardiology and Electrophysiology, Germany.
Toxicol Rep. 2021 Jul 9;8:1389-1393. doi: 10.1016/j.toxrep.2021.07.009. eCollection 2021.
Colchicine's medical evolution is historically bound to the Mediterranean basin, since remarkable researchers from this region underscored its valuable properties. With the passing of years colchicine became an essential pharmaceutical substance for the treatment of rheumatologic and cardiovascular diseases. In light of recent findings, the therapeutic value of colchicine has grown. In clinical practice, colchicine remains underutilized in view of its proven efficacy and safety. Its complex pharmacokinetics and multifaceted anti-inflammatory role remain under investigation. The current review addresses the safe administration of colchicine in view of key drug to drug interactions. Finally, we are briefly presenting colchicine's future potential applications.
秋水仙碱的医学发展在历史上与地中海盆地紧密相连，因为该地区的杰出研究人员强调了它的宝贵特性。随着时间的推移，秋水仙碱成为治疗风湿性和心血管疾病的重要药物。鉴于最近的研究发现，秋水仙碱的治疗价值有所提高。在临床实践中，鉴于其已证实的疗效和安全性，秋水仙碱仍未得到充分利用。其复杂的药代动力学和多方面的抗炎作用仍在研究中。本综述鉴于关键的药物相互作用探讨了秋水仙碱的安全给药。最后，我们简要介绍了秋水仙碱未来的潜在应用。
