一种新方法：将基础科学和社会公益相结合。
A FRESH approach: Combining basic science and social good.
机构信息
Thumbi Ndung'u is a professor and the scientific director of the HIV Pathogenesis Programme and Doris Duke Medical Research Institute, University of KwaZulu-Natal (UKZN), and an investigator at the Africa Health Research Institute, Durban 4001, South Africa; an investigator at the Ragon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA; and a group leader at the Max Planck Institute for Infection Biology, Berlin, Germany.
Krista L. Dong is a lecturer at Harvard Medical School; an assistant in Immunology at the Ragon Institute of MGH, MIT, and Harvard University, Cambridge, MA 02139, USA; and a lecturer in the Infectious Disease Division, Massachusetts General Hospital, Boston, MA 02114, USA.
出版信息
Sci Immunol. 2018 Sep 14;3(27). doi: 10.1126/sciimmunol.aau2798.
Abstract
A program to study HIV infection is empowering African women.
摘要
一项研究 HIV 感染的项目正在赋予非洲女性权力。
相似文献
1
A FRESH approach: Combining basic science and social good.一种新方法：将基础科学和社会公益相结合。
Sci Immunol. 2018 Sep 14;3(27). doi: 10.1126/sciimmunol.aau2798.
2
Tackling HIV by empowering adolescent girls and young women: a multisectoral, government led campaign in South Africa.通过增强青少年女孩和年轻妇女的权能来应对艾滋病毒：南非的一个多部门、政府主导的运动。
BMJ. 2018 Dec 7;363:k4585. doi: 10.1136/bmj.k4585.
3
Empowering sex workers? Critical reflections on peer-led risk-reduction workshops in Soweto, South Africa.赋予性工作者权力？对南非索韦托由同伴主导的风险降低工作坊的批判性反思。
Glob Health Action. 2019;12(1):1522149. doi: 10.1080/16549716.2018.1522149.
4
Peer education, gender and the development of critical consciousness: participatory HIV prevention by South African youth.同伴教育、性别与批判性意识的发展：南非青年参与式艾滋病毒预防
Soc Sci Med. 2002 Jul;55(2):331-45. doi: 10.1016/s0277-9536(01)00289-1.
5
Peer led HIV/AIDS prevention for women in South African informal settlements.同伴主导的南非非正式定居点女性艾滋病毒/艾滋病预防工作。
Health Care Women Int. 2003 Jul;24(6):502-12. doi: 10.1080/07399330303975.
6
Addressing adolescents' risk and protective factors related to risky behaviours: Findings from a school-based peer-education evaluation in the Western Cape.应对青少年与危险行为相关的风险和保护因素：西开普省一项基于学校的同伴教育评估结果
SAHARA J. 2016 Dec;13(1):197-207. doi: 10.1080/17290376.2016.1241188.
7
Poverty alleviation = good medicine.扶贫 = 良药。
S Afr Med J. 2003 Apr;93(4):240-1.
8
The impact of social environments on the effectiveness of youth HIV prevention: a South African case study.社会环境对青年艾滋病毒预防成效的影响：一项南非案例研究。
AIDS Care. 2005 May;17(4):471-8. doi: 10.1080/09540120412331319705.
9
Who are the peer educators? HIV prevention in South African schools.同伴教育者是谁？南非学校的艾滋病预防。
Health Educ Res. 2011 Jun;26(3):563-71. doi: 10.1093/her/cyq064. Epub 2010 Nov 15.
10
'I think condoms are good but, aai, I hate those things': condom use among adolescents and young people in a Southern African township.“我觉得避孕套挺好的，但是，哎呀，我讨厌那些东西”：南非一个城镇青少年和年轻人的避孕套使用情况
Soc Sci Med. 2001 Jun;52(11):1613-27. doi: 10.1016/s0277-9536(00)00272-0.
引用本文的文献
1
Slow virologic control but strong immune and metabolic recovery with dolutegravir-anchored therapy in an HIV cohort in Ghana.在加纳的一个艾滋病毒队列中，使用多替拉韦为主的治疗实现病毒学控制缓慢，但免疫和代谢恢复良好。
Virol J. 2025 Jul 19;22(1):247. doi: 10.1186/s12985-025-02873-w.
2
Antiretroviral therapy initiated during acute infection in women with HIV-1 clade C reduces anti-Tat antibody production and lowers CD8+ T cell activation.在感染HIV-1 C亚型的女性急性感染期开始抗逆转录病毒治疗，可减少抗Tat抗体产生并降低CD8+ T细胞活化。
Front Immunol. 2025 Jun 18;16:1564960. doi: 10.3389/fimmu.2025.1564960. eCollection 2025.
3
Distinct neutralization sensitivity between adult and infant transmitted/founder HIV-1 subtype C viruses to broadly neutralizing monoclonal antibodies.成人与婴儿传播/奠基者HIV-1 C型病毒对广泛中和单克隆抗体的中和敏感性存在差异。
PLoS Pathog. 2025 Jun 23;21(6):e1013245. doi: 10.1371/journal.ppat.1013245. eCollection 2025 Jun.
4
Distinct region-specific neutralization profiles of contemporary HIV-1 clade C against best-in-class broadly neutralizing antibodies.当代HIV-1 C亚型针对同类最佳广泛中和抗体的独特区域特异性中和谱。
J Virol. 2025 Jun 17;99(6):e0000825. doi: 10.1128/jvi.00008-25. Epub 2025 May 16.
5
Effect of the vaginal live biotherapeutic LACTIN-V (Lactobacillus crispatus CTV-05) on vaginal microbiota and genital tract inflammation among women at high risk of HIV acquisition in South Africa: a phase 2, randomised, placebo-controlled trial.阴道活性生物治疗剂LACTIN-V（卷曲乳杆菌CTV-05）对南非艾滋病病毒感染高危女性阴道微生物群和生殖道炎症的影响：一项2期随机安慰剂对照试验。
Lancet Microbe. 2025 Apr 3:101037. doi: 10.1016/j.lanmic.2024.101037.
6
The utility of nonhuman primate models for understanding acute HIV-1 infection.非人类灵长类动物模型在理解急性HIV-1感染方面的效用。
Curr Opin HIV AIDS. 2025 May 1;20(3):218-227. doi: 10.1097/COH.0000000000000920. Epub 2025 Mar 27.
7
Differences in HIV-1 reservoir size, landscape characteristics, and decay dynamics in acute and chronic treated HIV-1 Clade C infection.急性和慢性治疗的HIV-1 C亚型感染中HIV-1储存库大小、景观特征和衰减动态的差异。
Elife. 2025 Feb 20;13:RP96617. doi: 10.7554/eLife.96617.
8
Standard of prevention for infectious diseases' prevention clinical trials during pandemics: learning lessons for global policies from biomedical HIV prevention clinical trials and a case study of COVID-19.大流行期间传染病预防临床试验的预防标准：从生物医学HIV预防临床试验中汲取全球政策经验教训及COVID-19案例研究
Front Public Health. 2025 Jan 21;12:1539840. doi: 10.3389/fpubh.2024.1539840. eCollection 2024.
9
'It is scary to pause treatment': perspectives on HIV cure-related research and analytical treatment interruptions from women diagnosed during acute HIV in Durban, South Africa.“暂停治疗令人恐惧”：南非德班急性感染艾滋病毒女性对艾滋病毒治愈相关研究及分析性治疗中断的看法
HIV Res Clin Pract. 2025 Dec;26(1):2455917. doi: 10.1080/25787489.2025.2455917. Epub 2025 Jan 25.
10
Development of a latency model for HIV-1 subtype C and the impact of long terminal repeat element genetic variation on latency reversal.HIV-1 C亚型潜伏模型的建立及长末端重复序列基因变异对潜伏逆转的影响。
J Virus Erad. 2024 Dec 13;10(4):100575. doi: 10.1016/j.jve.2024.100575. eCollection 2024 Dec.
本文引用的文献
1
Detection and treatment of Fiebig stage I HIV-1 infection in young at-risk women in South Africa: a prospective cohort study.南非青年高危女性中 Fiebig 期 I 型 HIV-1 感染的检测与治疗：一项前瞻性队列研究。
Lancet HIV. 2018 Jan;5(1):e35-e44. doi: 10.1016/S2352-3018(17)30146-7. Epub 2017 Oct 1.
2
Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women.缺乏乳酸杆菌的宫颈阴道细菌群落与南非年轻女性感染艾滋病毒的风险增加有关。
Immunity. 2017 Jan 17;46(1):29-37. doi: 10.1016/j.immuni.2016.12.013. Epub 2017 Jan 10.
3
Association between injectable progestin-only contraceptives and HIV acquisition and HIV target cell frequency in the female genital tract in South African women: a prospective cohort study.南非女性中仅含注射用孕激素的避孕药与HIV感染及女性生殖道HIV靶细胞频率之间的关联：一项前瞻性队列研究
Lancet Infect Dis. 2016 Apr;16(4):441-8. doi: 10.1016/S1473-3099(15)00429-6. Epub 2015 Dec 24.
4
Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point.超急性HIV感染期间CD8 + T细胞活化的程度和动力学影响病毒载量设定值。
Immunity. 2015 Sep 15;43(3):591-604. doi: 10.1016/j.immuni.2015.08.012. Epub 2015 Sep 8.
5
Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract.宫颈阴道细菌是女性生殖道宿主炎症反应的主要调节因子。
Immunity. 2015 May 19;42(5):965-76. doi: 10.1016/j.immuni.2015.04.019.
Zotero 插件