Department of Oncology, People's Hospital of Yuxi City, the Sixth Affiliated Hospital of Kunming Medical University, Yuxi, Yunnan, 653100, China.
Department of Oncology, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, China.
Sci Rep. 2018 Sep 14;8(1):13801. doi: 10.1038/s41598-018-32257-w.
To investigate chemotherapy dosage-related cognitive impairment and its neural mechanisms in breast cancer (BC) patients. Twenty-eight breast cancer patients after each chemotherapy cycle and matched 29 healthy control subjects underwent structural magnetic resonance imaging. Voxel-based morphometry analysis was performed to compare group differences in the gray matter for the whole brain. Furthermore, mediation analysis was conducted to explore the role of brain structures in chemotherapy dosage-related cognitive impairment. Voxel-based morphometry analysis was performed in gray matter for the whole brain of BC patients after chemotherapy. The results revealed that the gray matter density in the left inferior frontal gyrus, right middle frontal gyrus, right fusiform area, and bilateral cerebellum was decreased in the BC patients compared to controls. The number of chemotherapy cycles was negatively associated with general cognitive capacity, verbal fluency and digit span performance in the BC patients. In addition, decreased gray matter density in the right middle frontal gyrus could mediate the chemotherapy dosage effects on verbal fluency performance. These findings indicate that the dose-response relationship between chemotherapy and cognitive impairment may depend on the decreases in gray matter density of the frontal cortical structures.
探讨乳腺癌患者化疗剂量相关认知功能障碍及其神经机制。
每化疗周期后，28 例乳腺癌患者和 29 名匹配的健康对照者接受结构磁共振成像。对全脑灰质进行基于体素的形态学分析，以比较组间差异。此外，还进行了中介分析，以探讨脑结构在化疗剂量相关认知障碍中的作用。对化疗后乳腺癌患者的全脑灰质进行基于体素的形态学分析。
与对照组相比，乳腺癌患者左侧额下回、右侧额中回、右侧梭状回和双侧小脑的灰质密度降低。化疗周期数与乳腺癌患者的总体认知能力、言语流畅性和数字跨度表现呈负相关。此外，右侧额中回的灰质密度降低可以介导化疗剂量对言语流畅性表现的影响。
化疗与认知功能障碍之间的剂量-反应关系可能取决于额皮质结构的灰质密度降低。
