Department of Pediatric Dentistry and Orthodontics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Laboratory for Nuclear Instrumentation, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Clin Oral Investig. 2019 Apr;23(4):1865-1870. doi: 10.1007/s00784-018-2644-2. Epub 2018 Sep 15.
To evaluate the potential of conventional glass ionomer cement (GIC), Biodentine™, MTA, and Portland cement to induce mineral density changes in carious dentin compared to zinc oxide eugenol control cement (ZOE).
Fifty blocks of bovine root dentin were prepared and a biofilm model using ATCC strains of S.mutans, S.sobrinus, and L.casei was used to promote artificial dentin lesions. After demineralization, the blocks were randomly divided into the five cement groups. Half of the surface of each specimen received the tested material and the other half was covered with wax (control). Samples were stored in phosphate buffered saline solution for 30 days and after that were scanned in a micro-CT with standardized parameters. Dentin mineral density changes were calculated using differences in plot profiles of the exposed and control carious dentin. Friedman's test, followed by Wilcoxon signed-rank test was used with 5% significance.
Mean ΔZ values for the cements were 48.63 ± 19.09 for the control (ZOE), 63.31 ± 32.59 for Biodentine™, 114.63 ± 72.92 for GIC, 109.56 ± 66.28 for MTA, and 106.88 ± 66.02 for Portland cement. All cements showed a statistically significant increase in ΔZ values compared to the control, but Biodentine™ values were statistically significantly lower compared to GIC and the other calcium silicate cements.
Tested materials present potential to induce mineral density changes in carious bovine dentin. MTA, Portland, and GIC showed higher bioactivity potential than Biodentine™.
Based on minimally invasive concept, materials with remineralization potential can be used to preserve diseased but still repairable dental tissue.
评估传统玻璃离子水门汀（GIC）、Biodentine™、MTA 和波特兰水泥与氧化锌丁香酚控制水泥（ZOE）相比，在诱导龋坏牙本质的矿化密度变化方面的潜力。
制备了 50 块牛根牙本质块，并使用 ATCC 株 S.mutans、S.sobrinus 和 L.casei 的生物膜模型来促进人工牙本质损伤。脱矿后，将块随机分为 5 个水泥组。每个标本的一半表面接受测试材料，另一半用蜡覆盖（对照）。样本在磷酸盐缓冲盐水溶液中储存 30 天，然后在具有标准化参数的微 CT 中扫描。使用暴露和对照龋坏牙本质的图轮廓差异计算牙本质矿化密度变化。使用 5%的显著性进行 Friedman 检验，然后进行 Wilcoxon 符号秩检验。
水泥的平均 ΔZ 值为对照（ZOE）为 48.63 ± 19.09，Biodentine™为 63.31 ± 32.59，GIC 为 114.63 ± 72.92，MTA 为 109.56 ± 66.28，波特兰水泥为 106.88 ± 66.02。与对照相比，所有水泥的 ΔZ 值均呈统计学显著增加，但 Biodentine™的值与 GIC 和其他硅酸钙水泥相比统计学显著降低。
测试材料在诱导牛龋牙本质矿化密度变化方面具有潜力。MTA、波特兰和 GIC 显示出比 Biodentine™更高的生物活性潜力。
基于微创概念，可以使用具有再矿化潜力的材料来保存患病但仍可修复的牙本质组织。
