Health Services and Systems Research, Duke-NUS Medical School, 169857, Singapore.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Atherosclerosis. 2018 Oct;277:163-168. doi: 10.1016/j.atherosclerosis.2018.08.045. Epub 2018 Sep 1.
CD36 is a cholesterol receptor involved in the uptake of oxidized low-density lipoprotein cholesterol and development of atherosclerotic plaques. Cross-sectional studies have shown correlations between plasma CD36 and atherosclerosis but no prospective study has examined the association yet. We prospectively examined the association between plasma CD36 levels and risk of incident coronary heart disease (CHD) in a Danish population.
Plasma CD36 levels were measured in a case-cohort study nested within the Danish population-based cohort, the Diet, Cancer and Health Study. A total of 1963 incident CHD events occurred between baseline (1993-1997) and 2008, and a sub-cohort of 1759 participants were randomly selected as reference. Cox proportional hazard regression models were used to compute the hazard ratio (HR) and corresponding 95% confidence interval (CI).
After adjusting for CHD risk factors, including history of hypercholesterolemia and diabetes, elevated plasma CD36 levels were not associated with higher CHD risk in the total population, and the HR comparing the highest versus lowest tertile of CD36 levels was 1.02 (95% CI: 0.84-1.23). High CD36 levels were only found to be associated with risk of CHD in combination with prevalent diabetes (HR = 2.83, 95% CI: 1.08-7.45) vs. the joint reference group of lowest CD36 tertile and no diabetes.
Plasma CD36 levels were not predictive of CHD risk in the general population.
CD36 是一种胆固醇受体，参与氧化型低密度脂蛋白胆固醇的摄取和动脉粥样硬化斑块的形成。横断面研究表明，血浆 CD36 与动脉粥样硬化之间存在相关性，但尚未有前瞻性研究对此进行检验。我们前瞻性地研究了丹麦人群中血浆 CD36 水平与冠心病（CHD）发病风险之间的关系。
在丹麦人群为基础的 Diet, Cancer and Health 研究中，我们在巢式病例对照研究中测量了血浆 CD36 水平。基线（1993-1997 年）至 2008 年间共发生了 1963 例 CHD 事件，从中随机选择了 1759 名参与者作为参考。我们使用 Cox 比例风险回归模型计算了危险比（HR）及其相应的 95%置信区间（CI）。
在调整了 CHD 危险因素，包括高胆固醇血症和糖尿病病史后，血浆 CD36 水平升高与总人群中更高的 CHD 风险无关，且最高与最低三分位 CD36 水平比较的 HR 为 1.02（95%CI：0.84-1.23）。仅发现 CD36 水平升高与合并糖尿病的 CHD 风险相关（HR=2.83，95%CI：1.08-7.45），而与最低 CD36 三分位和无糖尿病的联合参考组相比。
血浆 CD36 水平不能预测普通人群中 CHD 的发病风险。
