Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, 18 Shuangqing Road, Haidian District, Beijing 100085, PR China.
Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, 18 Shuangqing Road, Haidian District, Beijing 100085, PR China.
Ecotoxicol Environ Saf. 2018 Dec 15;165:476-483. doi: 10.1016/j.ecoenv.2018.09.036. Epub 2018 Sep 13.
Systematically evaluation of the metabolism, distribution and effect of imidacloprid in Chinese lizards (Eremias argus) were carried out following oral exposure. Imidacloprid-olefin-guanidine was prone to accumulate in the brain and caused potential neurotoxicity. Percutaneous and excretory excretions were the primary ways for the elimination of imidacloprid and its metabolites. Liver was the main site for hydroxy reduction and nitro-reduction metabolism of imidacloprid. The metabolism of imidacloprid was a complex process in which many metabolic enzymes participated. Aldehyde oxidase and CYP2C9 were the key enzymes in nitro-reduction process. CYP3A4 dominated the process of hydroxylation and desaturation. The increase in Glutathione S-transferase expression may be related to the removal of imidacloprid, but also related to the oxidative stress reaction that imidacloprid may cause in tissues, especially in the kidney. The findings enrich and supplement the knowledge of the environmental fate of imidacloprid in reptiles.
系统评估了吡虫啉在口服暴露后在中国蜥蜴（Eremias argus）中的代谢、分布和作用。吡虫啉-烯烃-胍易在脑中积累，引起潜在的神经毒性。经皮和排泄是吡虫啉及其代谢物的主要消除途径。肝脏是吡虫啉羟基还原和硝基还原代谢的主要部位。吡虫啉的代谢是一个复杂的过程，涉及多种代谢酶。醛氧化酶和 CYP2C9 是硝基还原过程中的关键酶。CYP3A4 主导着羟化和去饱和过程。谷胱甘肽 S-转移酶表达的增加可能与吡虫啉的去除有关，但也可能与吡虫啉在组织中引起的氧化应激反应有关，尤其是在肾脏中。这些发现丰富和补充了吡虫啉在爬行动物环境命运方面的知识。
