Department of Epidemiology, China Medical University, No. 77, Puhe Road, Shenyang North District, Shenyang, 110122, People's Republic of China.
School of Nursing, China Medical University, Shenyang, 110122, People's Republic of China.
BMC Cancer. 2018 Sep 15;18(1):893. doi: 10.1186/s12885-018-4795-6.
Long non-coding RNA (lncRNA) H19 is a hot spot in tumor development, progression and metastasis. This study assessed the association between H19 genetic polymorphisms and the susceptibility of lung cancer.
The case-control study was conducted to evaluate the association between four selected single nucleotide polymorphisms (rs217727, rs2107425, rs2735469 and rs17658052) in H19 gene and the risk of lung cancer. There were 556 female never smoking lung cancer patients and 395 cancer-free controls. Unconditional logistic regression analysis was used to analyze the associations between four SNPs and lung cancer risks by calculating the odds ratios and their 95% confidence intervals. The gene-environment interactions were assessed on both additive and multiplicative scales.
Compared with carriers carrying homozygous CC genotype, there was a statistically significant increased risk of lung cancer for carriers of the rs2107425 TT genotype (odds ratio = 1.599, 95%CI = 1.106-2.313, P = 0.013). In both dominant and recessive models, significant associations were found between rs2107425 and lung cancer risk, and the corresponding odds ratios were 1.346 (1.022-1.774) and 1.400 (1.011-1.937), with P values 0.035 and 0.043, respectively. There was no significant correlation between lung cancer risk and rs2735469, rs217727 and rs17658052. Interaction analysis showed that their combined effects had a greater impact on lung cancer than individual effects of polymorphism and cooking smoke exposure. However, further analysis showed that the both additive model and the multiplicative model were not statistically significant.
The polymorphism rs2107425 in H19 gene was associated with the risk of lung cancer among female who never smokes in Shenyang, China.
长链非编码 RNA（lncRNA）H19 是肿瘤发生、发展和转移的热点。本研究评估了 H19 基因遗传多态性与肺癌易感性之间的关系。
采用病例对照研究评估 H19 基因中四个选定的单核苷酸多态性（rs217727、rs2107425、rs2735469 和 rs17658052）与肺癌风险之间的关系。共有 556 名女性从不吸烟的肺癌患者和 395 名癌症对照组。采用条件 logistic 回归分析计算比值比及其 95%置信区间，分析四个 SNP 与肺癌风险之间的关联。在加性和乘法尺度上评估基因-环境相互作用。
与携带纯合 CC 基因型的携带者相比，rs2107425 TT 基因型的携带者患肺癌的风险显著增加（比值比=1.599，95%CI=1.106-2.313，P=0.013）。在显性和隐性模型中，rs2107425 与肺癌风险之间均存在显著关联，相应的比值比分别为 1.346（1.022-1.774）和 1.400（1.011-1.937），P 值分别为 0.035 和 0.043。rs2735469、rs217727 和 rs17658052 与肺癌风险无显著相关性。交互分析表明，它们的联合效应对肺癌的影响大于多态性和烹饪烟雾暴露的个体效应。然而，进一步的分析表明，加性模型和乘法模型均无统计学意义。
在中国沈阳，女性从不吸烟，H19 基因的多态性 rs2107425 与肺癌风险相关。
