Yamaguchi K, Abe K, Adachi I, Otsubo K, Nagasaki K, Suzuki M, Maruno K, Asanuma F, Tsuchihashi T, Miyake Y
Jpn J Clin Oncol. 1986 Sep;16(3):235-41.
Tissues of 50 small cell lung carcinomas were examined for production of 17 peptide hormones. Only when the concentration of a peptide detected in the tumor was 10 pmol or more per g wet weight, was the peptide considered to be produced by the tumor. The frequency of production of at least one of these peptide hormones was 84%, and that of two or more hormones was 50%. These results indicate that peptide hormone production is a very common phenomenon in small cell lung carcinoma. Of the peptide hormones examined, gastrin-releasing peptide is produced with the highest frequency, suggesting that this peptide could play an important role in small cell lung carcinoma.
对50例小细胞肺癌组织进行了17种肽类激素生成情况的检测。只有当肿瘤中检测到的某一肽类激素浓度达到每克湿重10皮摩尔或更高时，该肽类激素才被认为是由肿瘤产生的。这些肽类激素中至少有一种生成的频率为84%，两种或更多种激素生成的频率为50%。这些结果表明，肽类激素生成在小细胞肺癌中是一种非常常见的现象。在所检测的肽类激素中，胃泌素释放肽生成频率最高，提示该肽可能在小细胞肺癌中发挥重要作用。
