一种能大量产生抗利尿激素的人小细胞肺癌细胞系的建立。
Establishment of a human small cell lung cancer cell line producing a large amount of anti-diuretic hormone.
作者信息
Terasaki T, Matsuno Y, Shimosato Y, Yamaguchi K, Ichinose H, Nagatsu T, Kato K
机构信息
Pathology Division, National Cancer Center Hospital, Tokyo.
出版信息
Jpn J Cancer Res. 1994 Jul;85(7):718-22. doi: 10.1111/j.1349-7006.1994.tb02420.x.
Abstract
A new cancer cell line (Lu-165) producing a large amount of anti-diuretic hormone (ADH, 2.8 micrograms/g protein) was established from a 50-year-old small cell lung cancer patient presenting with a syndrome of inappropriate anti-diuretic hormone secretion. These cells grew well in serum-supplemented medium and during more than 100 passages they continued producing a large amount of this hormone. This cell line will be a useful tool for studies of the biochemistry and pathology of ADH-producing cancer.
摘要
从一名患有抗利尿激素分泌异常综合征的50岁小细胞肺癌患者体内建立了一种新的癌细胞系（Lu-165），该细胞系能产生大量抗利尿激素（ADH，2.8微克/克蛋白质）。这些细胞在添加血清的培养基中生长良好，在超过100次传代过程中，它们持续产生大量这种激素。该细胞系将成为研究产生ADH的癌症的生物化学和病理学的有用工具。
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