Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Oral Oncol. 2018 Oct;85:52-59. doi: 10.1016/j.oraloncology.2018.08.017. Epub 2018 Aug 30.
The aim of this study was to integrate the available data published on odontogenic carcinosarcoma into a comprehensive analysis of their features, treatment and recurrence. An electronic search with no publication date or language restriction was undertaken in March 2018 in the following databases: Medline Ovid, PubMed, Web of Science, Scopus and LILACS. Eligibility criteria included publications having enough clinical, imaginological and histopathological information to confirm a definite diagnosis of the neoplasm. Data were evaluated descriptively and statistically using the MedCalc software. The Kaplan-Meier method was used for survival analysis. The systematic review detected nine articles from eight countries. Six cases with no age predilection occurred in male individuals complaining of painful swelling in the posterior mandible. Radiographically, the lesions were large, with expansive radiolucency and with ill-defined borders and seven cases were associated with preexisting odontogenic lesions. Radical surgery was the treatment of choice in the majority of cases. Recurrences (n = 6), metastasis (n = 4) and death (n = 4) were frequently observed in many cases. Odontogenic carcinosarcoma is a very aggressive neoplasm with a poor prognosis. This study provides knowledge that could help surgeons, oncologists, otorhinolaryngologists and oral maxillofacial pathologists with the diagnosis and management of these lesions.
本研究旨在对已发表的牙源性癌肉瘤相关数据进行综合分析，以评估其特征、治疗方法和复发情况。2018 年 3 月，我们无发表日期和语言限制地在以下数据库中进行了电子检索：Ovid Medline、PubMed、Web of Science、Scopus 和 LILACS。纳入标准为：具有足够的临床、影像学和组织病理学信息以明确诊断肿瘤的出版物。使用 MedCalc 软件对数据进行描述性和统计学评估。Kaplan-Meier 法用于生存分析。系统评价从八个国家的九篇文章中检测到六例无年龄偏好的病例，这些病例均为男性，主诉为下颌后牙疼痛性肿胀。影像学上，病变较大，呈膨胀性透光性，边界不清，七例与先前存在的牙源性病变有关。大多数情况下，多数病例选择根治性手术治疗。复发（n=6）、转移（n=4）和死亡（n=4）在许多病例中经常发生。牙源性癌肉瘤是一种侵袭性很强的肿瘤，预后不良。本研究提供的知识可能有助于外科医生、肿瘤学家、耳鼻喉科医生和口腔颌面病理学家对这些病变进行诊断和治疗。
