Rahmat Abadi Asa, Daneste Hossein, Ranjbar Mohammad Ali, MScD Dmd
Postgraduate Student, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Dept. of Oral and Maxillofacial Surgery, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
J Dent (Shiraz). 2022 Sep;23(2 Suppl):419-423. doi: 10.30476/DENTJODS.2021.91880.1611.
Odontogenic carcinosarcoma is an extremely rare malignant mixed odontogenic tumor, in which both epithelial and mesenchymal component showing malignant cytology features. Due to paucity of reported cases, clinical appearance is unclear. Present study reports a mandibular odontogenic carcinosarcoma in a 33 years-old male with a history of painless mass in the anterior of mandible. The histopathological examination demonstrated a biphasic malignant neoplasm with both epithelial and mesenchymal component malignant features. There were follicles and strands of odontogenic epithelium, which were lined peripherally by ameloblast-like cells. Mesenchyme of tumor was highly cellular resembling dental papilla. Partial mandibular resection, consisting wide surgical excision with immediate reconstruction was accomplished.
牙源性癌肉瘤是一种极其罕见的恶性混合性牙源性肿瘤，其中上皮和间充质成分均表现出恶性细胞学特征。由于报道的病例较少，临床表现尚不清楚。本研究报告了一名33岁男性下颌牙源性癌肉瘤，该患者有下颌前部无痛性肿块病史。组织病理学检查显示为双相性恶性肿瘤，具有上皮和间充质成分的恶性特征。有牙源性上皮的滤泡和条索，其周边由成釉细胞样细胞衬里。肿瘤的间充质细胞高度密集，类似于牙乳头。完成了包括广泛手术切除并立即重建的部分下颌骨切除术。
