Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Carlton South, VIC, Australia; The Cooperative Research Centre (CRC) for Mental Health, VIC, Australia.
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Carlton South, VIC, Australia; The Cooperative Research Centre (CRC) for Mental Health, VIC, Australia; 1st Department of Psychiatry, Athens University Medical School, Eginition Hospital, Athens, Greece.
Schizophr Res. 2019 Feb;204:201-205. doi: 10.1016/j.schres.2018.09.008. Epub 2018 Sep 14.
We investigated IL1B genetic variation previously associated with risk for transition to psychosis for its association with gene expression in human post-mortem dorsolateral prefrontal cortex (DLPFC) from 74 (37 schizophrenia, 37 control) individuals and brain structure in 92 (44 schizophrenia, 48 control) living individuals. The IL1B A-G-T 'risk for psychosis transition' haplotype (rs16944|rs4848306|rs12621220) was associated with upregulation of IL1B mRNA expression in the DLPFC as well as reduced total grey matter and left middle frontal volumes and enlarged left lateral ventricular volume. Our results suggest IL1B genetic variation may confer psychosis risk via elevated mRNA expression and/or brain structure abnormalities.
我们研究了先前与精神病转化风险相关的 IL1B 基因变异，以探讨其与 74 名（37 名精神分裂症，37 名对照）个体死后的人背外侧前额叶皮质（DLPFC）中的基因表达以及 92 名（44 名精神分裂症，48 名对照）活体个体的脑结构的关联。IL1B A-G-T“精神病转化风险”单倍型（rs16944|rs4848306|rs12621220）与 DLPFC 中 IL1B mRNA 表达上调以及总灰质和左侧额中回体积减少以及左侧侧脑室体积增大有关。我们的研究结果表明，IL1B 基因变异可能通过增加 mRNA 表达和/或大脑结构异常来导致精神病风险。
