Baugh R F, Wolf G T, Beals T F, Krause C J, Forastiere A
Laryngoscope. 1986 Nov;96(11):1283-90. doi: 10.1002/lary.1986.96.11.1283.
Primary small cell carcinoma of the larynx is a rare malignancy with a dismal prognosis. A survey of the long-term follow-up from reported cases of small cell carcinoma of the larynx and a review of the recent experience with this tumor at the University of Michigan Hospitals was undertaken to determine if newer treatment approaches incorporating adjuvant chemotherapy were associated with prolonged survival. Median survival for those patients receiving adjuvant chemotherapy was 19 months compared to 11 months for patients treated with surgery and/or radiation therapy alone. Among patients treated initially with primary radiation therapy and adjuvant chemotherapy median survival was 55 months, which was significantly longer than any other treatment regimen (P = 0.02). Systemic chemotherapy and therapeutic irradiation appears to offer the least disabling and most efficacious form of current therapy.
原发性喉小细胞癌是一种罕见的恶性肿瘤，预后很差。对已报道的喉小细胞癌病例进行长期随访调查，并回顾密歇根大学医院近期对该肿瘤的治疗经验，以确定采用辅助化疗的新治疗方法是否能延长生存期。接受辅助化疗的患者中位生存期为19个月，而单纯接受手术和/或放射治疗的患者中位生存期为11个月。在最初接受原发性放射治疗和辅助化疗的患者中，中位生存期为55个月，明显长于任何其他治疗方案（P = 0.02）。全身化疗和放射治疗似乎是目前最不致残且最有效的治疗方式。
