Complex Management of Brain Metastases in Head and Neck Squamous Cell Carcinoma: A Case Report and Literature Review.

Head and neck squamous cell carcinoma (HNSCC) can, in rare instances, metastasize to the CNS, which is often associated with a poor prognosis. We present the case of a 65-year-old male with a history of HNSCC who developed two enhancing brain lesions: one in the right parietal region and another in the right insular region. Initially, the patient was managed with CyberKnife radiosurgery targeting both lesions. However, he later experienced neurological symptoms, including confusion, gait instability, and a left Jacksonian march, primarily attributed to the progression of the right parietal lesion. Given this symptomatic presentation, surgical resection of the lesion was performed to confirm the diagnosis and provide symptomatic relief. The surgical approach was selected based on the patient's clinical progression and imaging findings, with the goal of improving his quality of life. Despite surgical intervention, the patient's condition deteriorated, and he passed away seven months later. This case illustrates the complexity of treating CNS metastases from HNSCC, highlighting the challenges in surgical decision-making and the role of adjuvant therapies. The rarity of CNS metastases in HNSCC adds to the difficulty of management, underscoring the importance of a multidisciplinary approach. Further investigation is needed to develop standardized treatment protocols for such rare presentations. CNS metastases in HNSCC are uncommon and typically indicate a poor outcome. This case reinforces the need for ongoing research to enhance management strategies and improve patient survival in similar cases.