McDonald J D, Lin F K, Goldwasser E
Mol Cell Biol. 1986 Mar;6(3):842-8. doi: 10.1128/mcb.6.3.842-848.1986.
The gene for mouse erythropoietin was cloned and sequenced. We present here a preliminary analysis of the overall genomic organization of the coding portions and the two flanking regions of the gene. This is the third mammalian erythropoietin for which the sequence is available, but it represents the first from a nonprimate species. We investigated the evolutionary divergence of sequence and structure of the three erythropoietins and identified specific regions of the molecules that are apparently under various degrees, and perhaps different types, of functional constraint.
小鼠促红细胞生成素基因被克隆并测序。我们在此展示对该基因编码部分及其两侧两个区域的整体基因组组织的初步分析。这是第三个已获得序列的哺乳动物促红细胞生成素基因，但它是首个来自非灵长类物种的该基因。我们研究了这三种促红细胞生成素的序列和结构的进化差异，并确定了分子中明显受到不同程度、可能不同类型功能限制的特定区域。
