伊朗北部头颈癌的流行病学：来自戈勒斯坦省的一项10年趋势研究。

Epidemiology of Head and Neck Cancers in Northern Iran: A 10-Year Trend Study From Golestan Province.

作者信息

Taziki Mohammad-Hossein, Fazel Abdolreza, Salamat Fatemeh, Sedaghat Seyed-Mehdi, Ashaari Mohammad, Poustchi Hossein, Shakeri Ramin, Hoseinpoor Reza, Hasanpour-Heidari Susan, Roshandel Gholamreza

机构信息

Cancer Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.

出版信息

Arch Iran Med. 2018 Sep 1;21(9):406-411.

PMID:30221531

Abstract

BACKGROUND

Golestan province, in Northern Iran, is a high-risk area for esophageal squamous cell carcinoma (SCC). SCC is also the most common histological type of cancers of the head and neck region including cancers of oral cavity, oropharynx, hypopharynx and larynx. We aimed to present the incidence rate of head and neck SCC (HNSCC) in Golestan province during 2004 and 2013.

METHODS

Data on HNSCC were obtained from Golestan population-based cancer registry (GPCR). Quality control and data analysis were performed using CanReg software. Age standardized incidence rates (ASRs) were calculated using the world standard population. The ASRs were presented per 100000 person-years for different genders, residence places and years.

RESULTS

During the 10-year period from 2004-2013, 434 cases of HNSCC were registered. 327 (75.3%) of these cases were male, 51.2% (222 cases) lived in urban areas and 351 (80.9%) of the total HNSCCs occurred in the larynx. Overall, the ASR of HNSCCs in Golestan province was 4.8. The ASR of HNSCCs was more than two-fold higher in male (6.6) than female (3.0). Our results showed an increasing trend in ASR of larynx cancer during the study period both in male and female.

CONCLUSION

We found relatively high rates of larynx cancer in Golestan province. Our results also showed higher rates of HNSCC in males and urban population. Considering common risk factors between HNSCCs and esophageal cancer, further studies are needed to clarify different aspects of HNSCCs (including epidemiology and risk factors) in this high-risk population.

摘要

背景

伊朗北部的戈勒斯坦省是食管鳞状细胞癌（SCC）的高风险地区。SCC也是头颈部区域癌症最常见的组织学类型，包括口腔癌、口咽癌、下咽癌和喉癌。我们旨在呈现2004年至2013年期间戈勒斯坦省头颈部SCC（HNSCC）的发病率。

方法

HNSCC的数据来自戈勒斯坦省基于人群的癌症登记处（GPCR）。使用CanReg软件进行质量控制和数据分析。年龄标准化发病率（ASR）采用世界标准人口计算。按每100000人年呈现不同性别、居住地和年份的ASR。

结果

在2004 - 2013年的10年期间，共登记了434例HNSCC病例。其中327例（75.3%）为男性，51.2%（222例）居住在城市地区，80.9%（351例）的HNSCC发生在喉部。总体而言，戈勒斯坦省HNSCC的ASR为4.8。男性HNSCC的ASR（6.6）比女性（3.0）高出两倍多。我们的结果显示，在研究期间，男性和女性的喉癌ASR均呈上升趋势。