Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
J Dermatol. 2018 Dec;45(12):1468-1470. doi: 10.1111/1346-8138.14647. Epub 2018 Sep 17.
Psoriasis is a chronic inflammatory systemic disease. Growing evidence suggests that human homeostasis depends on a mutualistic relationship with gut bacteria that produce a number of biologically active compounds. Therefore, enteric microbiota dysbiosis with gut barrier disruption may be an important factor in the development of chronic inflammatory diseases. The aim of our study was to assess non-invasive markers of intestinal barrier integrity in patients with moderate to severe psoriasis. Concentrations of claudin-3 (intestinal epithelial tight junction structure) and intestinal fatty acid binding protein (I-FABP; marker of enterocyte damage) were determined in the blood of patients with chronic plaque psoriasis (n = 20) and healthy individuals (n = 20) using commercially available enzyme-linked immunoassay test kits. Claudin-3 concentration was higher in patients with psoriasis compared with healthy control (median, 54.07 vs 42.36 ng/mL; P < 0.001). Patients with psoriasis also had elevated concentration of plasma I-FABP (median, 708.8 vs 147.1 pg/mL; P < 0.05). Our results support the hypothesis that dysfunction of the intestinal barrier in psoriasis disturbs the homeostatic equilibrium between the microbiota and immune system. Further studies are needed in order to develop new therapeutic interventions based on modulation of intestinal permeability.
银屑病是一种慢性炎症性全身性疾病。越来越多的证据表明，人类的内稳态依赖于与肠道细菌的共生关系，这些细菌产生许多具有生物活性的化合物。因此，肠道微生物群落失调和肠道屏障破坏可能是慢性炎症性疾病发展的一个重要因素。我们的研究旨在评估中重度银屑病患者的肠道屏障完整性的非侵入性标志物。使用商业上可用的酶联免疫吸附试验试剂盒，在慢性斑块状银屑病患者（n=20）和健康个体（n=20）的血液中测定紧密连接结构蛋白-3（肠道上皮紧密连接结构）和肠脂肪酸结合蛋白（I-FABP；肠细胞损伤的标志物）的浓度。与健康对照组相比，银屑病患者的 claudin-3 浓度更高（中位数，54.07 与 42.36ng/mL；P<0.001）。银屑病患者的血浆 I-FABP 浓度也升高（中位数，708.8 与 147.1pg/mL；P<0.05）。我们的结果支持这样一种假设，即银屑病中肠道屏障功能障碍扰乱了微生物群和免疫系统之间的内稳态平衡。需要进一步研究以开发基于肠道通透性调节的新治疗干预措施。
