Grine Lynda, Hilhorst Niels, Michels Nathalie, Abbeddou Souheila, De Henauw Stefaan, Lambert Jo
Dermatology Research Unit, Department of Head and Skin, Ghent University, Ghent, Belgium.
Department of Dermatology, Ghent University Hospital, Ghent, Belgium.
JMIR Res Protoc. 2022 Feb 23;11(2):e26405. doi: 10.2196/26405.
Psoriasis is a complex disease associated with multiple comorbidities, including metabolic syndrome and leaky gut syndrome. Dietary lifestyle interventions have been reported to affect the disease in terms of lesional severity. It remains unclear how diets affect these comorbidities and the general health in psoriasis patients. Modified intermittent fasting (MIF) on 2 nonconsecutive days has shown beneficial effects on metabolic parameters. A significant advantage of MIF over the currently investigated dietary changes is its feasibility.
Here, we aim to study the effects of MIF on skin, gut, and metabolic health in psoriasis patients.
A 2-arm pilot randomized controlled open cross-over study will be performed in 24 patients with psoriasis. Patients will be randomized 1:1 to either start with 12 weeks of MIF and go on a subsequent regular diet for another 12 weeks or start with 12 weeks of regular diet and do subsequent MIF for 12 weeks. The following parameters will be assessed: demographics, disease phenotype, medical and familial history, psoriasis severity, dermatology-specific and general quality of life, nutritional and physical habits, mental and intestinal health, intestinal and cutaneous integrity, inflammatory and metabolic markers, and satisfaction.
A total of 24 participants have been enrolled in the study. The final visit is foreseen for June 2021.
The aim is to uncover the effects of MIF on psoriasis severity and gut health integrity through clinical and molecular investigation. More precisely, we want to map the evolution of the different markers, such as psoriasis severity, permeability, and inflammation, in response to MIF as compared to a regular diet,. Understanding how dietary lifestyles can affect epithelial lineages, such as the skin and gut, will greatly improve our understanding of the development of psoriasis and may offer a nonpharmacological venue for treatments.
ClinicalTrials.gov NCT04418791; https://clinicaltrials.gov/ct2/show/NCT04418791.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/26405.
银屑病是一种与多种合并症相关的复杂疾病，包括代谢综合征和肠道渗漏综合征。据报道，饮食生活方式干预会对该病的皮损严重程度产生影响。目前尚不清楚饮食如何影响银屑病患者的这些合并症和整体健康状况。非连续两天的改良间歇性禁食（MIF）已显示出对代谢参数有有益影响。MIF相对于目前所研究的饮食变化的一个显著优势在于其可行性。
在此，我们旨在研究MIF对银屑病患者皮肤、肠道和代谢健康的影响。
将对24例银屑病患者进行一项双臂试点随机对照开放交叉研究。患者将按1:1随机分组，要么先进行12周的MIF，随后再进行12周的常规饮食，要么先进行12周的常规饮食，随后再进行12周的MIF。将评估以下参数：人口统计学特征、疾病表型、病史和家族史、银屑病严重程度、皮肤病学特异性和总体生活质量、营养和身体习惯、心理和肠道健康、肠道和皮肤完整性、炎症和代谢标志物以及满意度。
共有24名参与者入组该研究。预计最后一次访视时间为2021年6月。
目的是通过临床和分子研究揭示MIF对银屑病严重程度和肠道健康完整性的影响。更确切地说，我们想描绘不同标志物（如银屑病严重程度、通透性和炎症）相对于常规饮食在MIF作用下的演变情况。了解饮食生活方式如何影响上皮谱系（如皮肤和肠道）将极大地增进我们对银屑病发病机制的理解，并可能提供一种非药物治疗途径。
ClinicalTrials.gov NCT04418791；https://clinicaltrials.gov/ct2/show/NCT04418791。
国际注册报告识别码（IRRID）：DERR1-10.2196/26405。
