Nowowiejska Julia, Baran Anna, Flisiak Iwona
Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St., 15-540 Bialystok, Poland.
Metabolites. 2022 Sep 3;12(9):833. doi: 10.3390/metabo12090833.
Psoriasis is one of the most common skin diseases in dermatological practice. It affects about 1-3% of the general population and is associated with different comorbidities, especially metabolic syndrome. Fatty-acid-binding proteins (FABPs) are a family of cytosolic proteins which are an important link in lipid metabolism and transport; moreover, they have different tissue specificity and properties. So far, ten FABPs have been discovered and seven have been investigated in psoriasis. In this review, we discuss the nature of all FABPs and their role in psoriasis. FABPs have different organ and tissue expression, and hence various functions, and may be markers of different disorders. Considering the concentration of a few of them tends to be elevated in psoriasis, it confirms the current perception of psoriasis as a multiorgan disorder associated with plenty of comorbidities. Some FABPs may be also further investigated as biomarkers of psoriasis organ complications. FABP-1 and FABP-5 may become potential markers of metabolic complications and inflammation in psoriasis. FABP-7 could perhaps be further investigated as an indicator of the neurodegenerative processes in psoriatic patients.
银屑病是皮肤科临床中最常见的皮肤病之一。它影响着约1%-3%的普通人群，并与多种合并症相关，尤其是代谢综合征。脂肪酸结合蛋白（FABPs）是一类胞质蛋白家族，是脂质代谢和转运的重要环节；此外，它们具有不同的组织特异性和特性。到目前为止，已发现十种FABPs，其中七种已在银屑病中进行了研究。在本综述中，我们讨论了所有FABPs的性质及其在银屑病中的作用。FABPs在不同器官和组织中表达，因此具有多种功能，可能是不同疾病的标志物。鉴于其中一些在银屑病中的浓度往往会升高，这证实了目前将银屑病视为一种与多种合并症相关的多器官疾病的观点。一些FABPs也可能作为银屑病器官并发症的生物标志物进一步研究。FABP-1和FABP-5可能成为银屑病代谢并发症和炎症的潜在标志物。FABP-7或许可以作为银屑病患者神经退行性变过程的指标进一步研究。
