Nambiar Monessha, Wang Li-Sheng, Rotello Vincent, Chmielewski Jean
Department of Chemistry , Purdue University , 560 Oval Drive , West Lafayette , Indiana 47907-2084 , United States.
Department of Chemistry , University of Massachusetts-Amherst , 710 N. Pleasant Street , Amherst , Massachusetts 01002 , United States.
J Am Chem Soc. 2018 Oct 10;140(40):13028-13033. doi: 10.1021/jacs.8b08163. Epub 2018 Oct 1.
We report a set of coiled-coil peptides, radially functionalized with bipyridines, that demonstrate hierarchical assembly into banded rectangular nano- and microstructures, the dimensions of which vary with the strategic placement and number of aromatic groups on the monomer backbone. Finer structural aspects of the hexagonal packing of the individual trimers were determined by X-ray scattering, including intertrimer aromatic interactions between bipyridine moieties. The ease of formation of these biomaterials under physiological conditions and the use of pH to reversibly modulate assembly demonstrate future potential for a range of biological applications, such as drug delivery in a pH-controlled manner.
我们报道了一组用联吡啶进行径向功能化的卷曲螺旋肽，它们能分级组装成带状矩形纳米和微结构，其尺寸随单体主链上芳香基团的策略性布局和数量而变化。通过X射线散射确定了单个三聚体六方堆积的更精细结构方面，包括联吡啶部分之间的三聚体间芳香相互作用。这些生物材料在生理条件下易于形成，且利用pH值可逆地调节组装，这表明其在一系列生物应用中具有未来潜力，例如以pH值控制的方式进行药物递送。
