Bordoloi Meelie, Ramtekkar Ujjwal
Department of Psychiatry, University of Missouri, Columbia, MO 65212, USA.
Department of Psychiatry, Nationwide Children's Hospital, Columbus, OH 43025, USA.
Med Sci (Basel). 2018 Sep 14;6(3):76. doi: 10.3390/medsci6030076.
Sleep disorders are common in several psychiatric disorders, including schizophrenia. In the pediatric population, the relationship between sleep and psychosis is not completely understood due to limited research studies investigating the link. Insomnia is noted to be a predictor of psychosis, especially in ultrahigh risk adolescents. Sleep difficulties are also associated with a two to three-fold increase in paranoid thinking. Biological factors, such as decrease in thalamic volume, have been observed in children with schizophrenia and ultrahigh risk adolescents with associated sleep impairment. Objective studies have indicated possible actigraphy base measures to be the predictor of psychosis after a one year follow-up. The studies using polysomnography have rare and inconsistent results. In this brief review, we provide an overview of existing literature. We also posit that future research will be beneficial in understanding the initiation, course and progression of sleep disturbance in the high risk pediatric population with the goal of implementing interventions to alter the development of psychosis.
睡眠障碍在包括精神分裂症在内的多种精神疾病中很常见。在儿科人群中，由于研究睡眠与精神病之间联系的研究有限，二者之间的关系尚未完全明了。失眠被认为是精神病的一个预测指标，尤其是在超高风险的青少年中。睡眠困难还与偏执思维增加两到三倍有关。在患有精神分裂症的儿童和有相关睡眠障碍的超高风险青少年中，已观察到生物因素，如丘脑体积减小。客观研究表明，经过一年的随访，基于活动记录仪的测量可能是精神病的预测指标。使用多导睡眠图的研究结果罕见且不一致。在这篇简要综述中，我们概述了现有文献。我们还认为，未来的研究将有助于了解高危儿科人群睡眠障碍的起始、过程和进展，目标是实施干预措施以改变精神病的发展。
