Mullick F G, Drake R M, Irey N S
Hum Pathol. 1977 Jul;8(4):361-78. doi: 10.1016/s0046-8177(77)80002-6.
The morphologic findings in 102 validated cases of adverse drug reactions classified in the "causative" and "probable" category are reported. All of them are well documented cases of drug associated reactions. The patterns of tissue reactions in these cases are divided into the following categories: inflammation, degeneration and infiltration, hypoplasia and aplasia, hyperplasia, necrosis, circulatory disturbances and vascular abnormalities, and teratogenesis. Degeneration and infiltration constitute the most common tissue reaction pattern present in these cases. The liver is the organ most frequently affected. Anti-infective drugs were associated with the highest number of adverse drug reactions, followed by antineoplastic drugs.
报告了102例被归类为“因果关系明确”和“很可能”的药物不良反应确诊病例的形态学研究结果。所有这些都是药物相关反应的充分记录病例。这些病例中的组织反应模式分为以下几类：炎症、变性和浸润、发育不全和发育不全、增生、坏死、循环障碍和血管异常以及致畸作用。变性和浸润是这些病例中最常见的组织反应模式。肝脏是最常受影响的器官。抗感染药物导致的药物不良反应数量最多，其次是抗肿瘤药物。
