文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Castleden C M, Pickles H

Department of Geriatric Medicine, Leicester General Hospital.

Br J Clin Pharmacol. 1988 Oct;26(4):347-53. doi: 10.1111/j.1365-2125.1988.tb03391.x.

Spontaneous reports of suspected adverse drug reactions (ADRs) reported to the Committee on Safety of Medicines (CSM) have been studied in relation to patient age. 2. The proportion of reports received for the elderly increased between 1965 and 1983. 3. There was a correlation between the use of drugs and the number of ADR reports. Thus age-related prescription figures for two non-steroidal anti-inflammatory drugs (NSAI) and co-trimoxazole matched ADR reports for each drug in each age group. 4. The reported ADR was more likely to be serious or fatal in the elderly. 5. The commonest ADRs reported for the elderly affected the gastrointestinal (GIT) and haemopoietic systems, where more reports were received than would be expected from prescription figures. 6. The drug suspected of causing a GIT reaction was a NSAI in 75% of the reports. 7. Ninety-one per cent of fatal reports of GIT bleeds and perforations associated with NSAI drugs were in patients over 60 years of age.

已针对患者年龄对向药品安全委员会（CSM）报告的疑似药物不良反应（ADR）自发报告进行了研究。2. 1965年至1983年间，收到的针对老年人的报告比例有所增加。3. 药物使用与ADR报告数量之间存在相关性。因此，两种非甾体抗炎药（NSAIDs）和复方新诺明的年龄相关处方数字与各年龄组中每种药物的ADR报告相匹配。4. 报告的ADR在老年人中更有可能是严重的或致命的。5. 针对老年人报告的最常见ADR影响胃肠道（GIT）和造血系统，在这些系统中收到的报告比根据处方数字预期的要多。6. 在75%的报告中，怀疑引起GIT反应的药物是一种NSAID。7. 与NSAID药物相关的GIT出血和穿孔的致命报告中有91%发生在60岁以上的患者中。

Castleden C M, Pickles H

Department of Geriatric Medicine, Leicester General Hospital.

Br J Clin Pharmacol. 1988 Oct;26(4):347-53. doi: 10.1111/j.1365-2125.1988.tb03391.x.

Spontaneous reports of suspected adverse drug reactions (ADRs) reported to the Committee on Safety of Medicines (CSM) have been studied in relation to patient age. 2. The proportion of reports received for the elderly increased between 1965 and 1983. 3. There was a correlation between the use of drugs and the number of ADR reports. Thus age-related prescription figures for two non-steroidal anti-inflammatory drugs (NSAI) and co-trimoxazole matched ADR reports for each drug in each age group. 4. The reported ADR was more likely to be serious or fatal in the elderly. 5. The commonest ADRs reported for the elderly affected the gastrointestinal (GIT) and haemopoietic systems, where more reports were received than would be expected from prescription figures. 6. The drug suspected of causing a GIT reaction was a NSAI in 75% of the reports. 7. Ninety-one per cent of fatal reports of GIT bleeds and perforations associated with NSAI drugs were in patients over 60 years of age.

已针对患者年龄对向药品安全委员会（CSM）报告的疑似药物不良反应（ADR）自发报告进行了研究。2. 1965年至1983年间，收到的针对老年人的报告比例有所增加。3. 药物使用与ADR报告数量之间存在相关性。因此，两种非甾体抗炎药（NSAIDs）和复方新诺明的年龄相关处方数字与各年龄组中每种药物的ADR报告相匹配。4. 报告的ADR在老年人中更有可能是严重的或致命的。5. 针对老年人报告的最常见ADR影响胃肠道（GIT）和造血系统，在这些系统中收到的报告比根据处方数字预期的要多。6. 在75%的报告中，怀疑引起GIT反应的药物是一种NSAID。7. 与NSAID药物相关的GIT出血和穿孔的致命报告中有91%发生在60岁以上的患者中。