Mikhael N Z, Kacew S
Hum Toxicol. 1985 Nov;4(6):583-90. doi: 10.1177/096032718500400604.
Over a 5-year duration a total number of 57 881 tissue specimens from hospitalized patients were evaluated clinicopathologically for evidence of adverse tissue reactions to drugs. The incidence of alleged adverse tissue reactions was 3.7% of which 1.5% were definitely shown to be caused by a specific pharmacological agent. Regardless of the category of the adverse tissue reaction, the frequency of drug-related responses occurred most often in females, especially between the ages of 41 and 60 years. The target tissue affected adversely most often was endometrium where hyperplasia was the predominant response noted. An oestrogenic preparation was found most frequently to be implicated in the observed adverse tissue reaction. Evaluation of adverse drug reactions with the use of morphologic technique provides a rigorous and reliable mechanism to monitor deleterious effects in hospitalized patients.
在5年期间，对来自住院患者的总共57881份组织标本进行了临床病理评估，以寻找药物引起的不良组织反应的证据。据称不良组织反应的发生率为3.7%，其中1.5%被明确证明是由特定药理剂引起的。无论不良组织反应的类别如何，药物相关反应的频率在女性中最常出现，尤其是在41至60岁之间。最常受到不利影响的靶组织是子宫内膜，其中增生是主要观察到的反应。发现雌激素制剂最常与观察到的不良组织反应有关。使用形态学技术评估药物不良反应为监测住院患者的有害影响提供了一种严谨且可靠的机制。
