1 Institute of Legal Medicine, Faculty of Medicine, University of Cologne, Cologne, Germany.
2 EMPA Material Science and Technology, St. Gallen, Switzerland.
J Biomater Appl. 2018 Sep;33(3):327-339. doi: 10.1177/0885328218793488.
The deposition of coatings enabling antibacterial properties in combination with cytocompatibility remains a challenge for biomaterial applications, such as in medical devices. Silver is one of the most utilized antibacterial surface components, due to its efficacy and extensive applicability. In this work, silver-containing plasma polymer nanocomposites (single layer and multilayers) were developed and tested, with a focus on cytotoxicity and bactericidal function, on the NIH3T3 mammalian cell line as well as Gram-negative ( Pseudomonas aeruginosa) and Gram-positive ( Staphylococcus aureus) bacterial strains. The data demonstrate that a tuneable Ag release is required, allowing sufficient antimicrobial activity while retaining appropriate cytocompatibility over the entire testing period of up to eight days.
涂层的沉积使得抗菌性能与细胞相容性相结合，这仍然是生物材料应用（例如医疗器械）的一个挑战。由于其功效和广泛适用性，银是最常用的抗菌表面成分之一。在这项工作中，开发并测试了含有银的等离子体聚合物纳米复合材料（单层和多层），重点关注 NIH3T3 哺乳动物细胞系以及革兰氏阴性（铜绿假单胞菌）和革兰氏阳性（金黄色葡萄球菌）细菌菌株的细胞毒性和杀菌功能。数据表明，需要可调的 Ag 释放，以在整个长达八天的测试期间内保持适当的细胞相容性的同时，提供足够的抗菌活性。
