The Department of pharmaceutical Engineering (State Key Laboratory of Functions and Applications of Medicinal Plants, the Key Laboratory of Optimal Utilization of Natural Medicine Resources), School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 550025, China.
School of Chemical Engineering, Guizhou Minzu University, Guiyang, Guizhou, 550025, China.
J Mater Sci Mater Med. 2019 Mar 6;30(3):34. doi: 10.1007/s10856-019-6236-8.
Antimicrobial resistance to traditional antibiotics leads to a serious concern for medical care owing to ineffective antibiotic therapies. This study focused on the preparation of silver nanocomposites (AgNPs@Tob&PAGA) by modifying AgNPs with tobramycin (Tob) and carbohydrate polymer of poly(2-(acrylamido) glucopyranose) (PAGA). The enhanced antibacterial activities of nanocomposites against common pathogens of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) were explored. The introduction of PAGA onto silver nanocomposites improved both citocompatibility and antibacterial activity. Compared with nude Tob, AgNPs@Tob&PAGA showed more fascinating antimicrobial effect against E. coli and S. aureus with about 20-fold increase in the antibacterial activity, simultaneously no detectable resistance was observed. Consequently, the silver nanocomposite as an antimicrobial agent presents promising prospects in the treatment of bacterial infections caused by antimicrobial resistant bacteria.
由于抗生素治疗效果不佳，传统抗生素的抗药性导致医疗保健受到严重关注。本研究通过用妥布霉素 (Tob) 和多糖聚合物聚 (2-(丙烯酰胺基) 葡萄糖) (PAGA) 修饰银纳米颗粒 (AgNPs)，制备了银纳米复合材料 (AgNPs@Tob&PAGA)。探讨了纳米复合材料对大肠杆菌 (E. coli) 和金黄色葡萄球菌 (S. aureus) 等常见病原体的增强抗菌活性。在银纳米复合材料上引入 PAGA 提高了细胞相容性和抗菌活性。与裸妥布霉素相比，AgNPs@Tob&PAGA 对大肠杆菌和金黄色葡萄球菌表现出更显著的抗菌效果，抗菌活性提高了约 20 倍，同时没有观察到耐药性。因此，作为一种抗菌剂，银纳米复合材料在治疗由耐药菌引起的细菌感染方面具有广阔的应用前景。
