抗凝剂：药代动力学、作用机制及适应症
Anticoagulants: Pharmacokinetics, Mechanisms of Action, and Indications.
作者信息
DeWald Tracy A, Washam Jeffrey B, Becker Richard C
机构信息
Department of Medicine, Duke Heart Center, DUMC Box 3943, Durham, NC 27710, USA.
Department of Medicine, University of Cincinnati Heart, Lung and Vascular Institute, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 542, Cincinnati, OH 45267, USA.
出版信息
Neurosurg Clin N Am. 2018 Oct;29(4):503-515. doi: 10.1016/j.nec.2018.06.003. Epub 2018 Jul 23.
Anticoagulant medications are used widely for a variety of medical and surgical diseases, disorders, and conditions associated with thrombosis and thromboembolism. This review highlights labeled indications, mechanisms of action, potential drug interactions, and specific pharmacokinetic characteristics of available anticoagulants as an essential foundation for guiding selection and management of therapies for patients undergoing neurosurgical procedures.
抗凝血药物广泛应用于各种与血栓形成和血栓栓塞相关的内科及外科疾病、紊乱和病症。本综述重点介绍了现有抗凝血剂的标注适应症、作用机制、潜在药物相互作用以及特定药代动力学特征，作为指导神经外科手术患者治疗选择和管理的重要基础。
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