Gusdorf L, Lipsker D
Dermatology Department, Hôpitaux Universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg, France.
Dermatology Department, Hôpitaux Universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg, France.
Ann Dermatol Venereol. 2018 Dec;145(12):735-740. doi: 10.1016/j.annder.2018.06.010. Epub 2018 Sep 14.
Neutrophilic urticarial dermatosis (NUD) is a rare form of dermatosis. In clinical terms, it consists of a chronic or recurrent eruption comprising slightly elevated, pink to reddish plaques or macules. The elementary lesion lasts 24 to 48hours and resolves without leaving any residual pigmentation. Extra-cutaneous signs are common, particularly fever or arthralgia. At histopathology, the dermis contains dense neutrophilic interstitial infiltrate with leukocytoclasis, but without fibrinoid necrosis of vessel walls. NUD often occurs in a setting of underlying systemic disease. The most commonly associated diseases are adult-onset Still's disease, Schnitzler syndrome, lupus erythematosus and cryopyrin-associated periodic syndromes. Treatment of NUD depends on the clinical context. Dapsone and colchicine are often effective.
嗜中性荨麻疹性皮肤病（NUD）是一种罕见的皮肤病形式。从临床角度来看，它表现为慢性或复发性皮疹，由略微隆起的粉红色至红色斑块或斑疹组成。基本损害持续24至48小时，消退后不留任何色素沉着。皮肤外体征很常见，尤其是发热或关节痛。在组织病理学上，真皮含有密集的嗜中性间质浸润并伴有白细胞破碎，但血管壁无纤维蛋白样坏死。NUD常发生于潜在的全身性疾病背景下。最常相关的疾病是成人斯蒂尔病、施尼茨勒综合征、红斑狼疮和冷吡啉相关周期性综合征。NUD的治疗取决于临床情况。氨苯砜和秋水仙碱通常有效。
