Center for Dermatology Research, Department of Dermatology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157-1071, USA.
Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Am J Clin Dermatol. 2024 Sep;25(5):811-822. doi: 10.1007/s40257-024-00879-8. Epub 2024 Jul 30.
Dapsone, initially synthesized for textile dyeing, gained recognition in the 1930s for its antibacterial properties, leading to its utilization in dermatology for leprosy and dermatitis herpetiformis. Despite US Food and Drug Administration (FDA) approval for these conditions, dapsone's off-label uses have expanded, making it a valuable option in various dermatologic conditions. This review seeks to highlight the common uses of dapsone in its FDA indications and off-label indications. Diseases in which dapsone is considered first-line therapy or adjunctive therapy are reviewed, with highlights from the resources included. An overview of dapsone's pharmacokinetics, pharmacodynamics, indications, dosages, and safety profile are also reviewed. Dapsone's versatility and safety profile make it a cost-effective treatment option in dermatology, particularly for patients with limited access to specialized medications. Ongoing clinical trials are also described exploring dapsone's efficacy in novel dermatologic uses. Dapsone has been a valuable adjunctive therapy across various dermatologic conditions for years and evidence for its use continues to expand.
苯佐卡因，最初用于纺织品染色，在 20 世纪 30 年代因其抗菌特性而受到认可，随后被用于麻风病和疱疹样皮炎的皮肤科治疗。尽管美国食品和药物管理局 (FDA) 批准了这些适应症，但苯佐卡因的非适应症用途已经扩大，使其成为各种皮肤科疾病的有效治疗选择。本综述旨在强调苯佐卡因在 FDA 适应症和非适应症中的常见用途。本文回顾了苯佐卡因在被认为是一线治疗或辅助治疗的疾病中的应用，并重点介绍了所纳入资源的情况。本文还概述了苯佐卡因的药代动力学、药效学、适应症、剂量和安全性概况。苯佐卡因的多功能性和安全性使其成为皮肤科的一种具有成本效益的治疗选择，特别是对于那些难以获得专门药物的患者。本文还描述了正在进行的临床试验，探讨了苯佐卡因在新型皮肤科用途中的疗效。多年来，苯佐卡因一直是各种皮肤科疾病的有效辅助治疗药物，其应用证据不断扩大。
