Epidemiological Cardiology Research Center (EPICARE), Department of Epidemiology and Prevention, and Department of Medicine, Section on Cardiology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, United States.
Trends Cardiovasc Med. 2019 May;29(4):239-244. doi: 10.1016/j.tcm.2018.09.004. Epub 2018 Sep 8.
Coronary heart disease (CHD) is the most common underlying risk factor for heart failure (HF); up to one-third of the patients who are hospitalized for HF each year in the United States have a history of myocardial infarction (MI). Although silent MI (SMI) could account for up to one-half of all MIs, only a few studies examined the relationship between SMI and risk of HF. These few studies agreed on their conclusions that SMI is associated with increased risk of HF. However, there was less agreement on the magnitude of risk and the sex differences in the association between SMI and HF, which is probably due to the heterogeneity in how these studies defined SMI. This report summarizes and discusses the current evidence linking SMI to HF, the impact of the methods by which SMI is defined on the reported relationship between SMI and HF, the potential mechanisms for such relationship, the implications of these findings, and the gaps in knowledge that need to be addressed.
冠心病（CHD）是心力衰竭（HF）最常见的潜在风险因素；在美国，每年因 HF 住院的患者中，多达三分之一有心肌梗死（MI）病史。尽管无症状性 MI（SMI）可能占所有 MI 的一半以上，但只有少数研究探讨了 SMI 与 HF 风险之间的关系。这些为数不多的研究在其结论上达成一致，即 SMI 与 HF 风险增加相关。然而，对于 SMI 与 HF 之间关联的风险程度和性别差异，研究结果的一致性较低，这可能是由于这些研究定义 SMI 的方法存在异质性。本报告总结并讨论了将 SMI 与 HF 联系起来的现有证据、定义 SMI 的方法对报告的 SMI 与 HF 之间关系的影响、这种关系的潜在机制、这些发现的意义以及需要解决的知识空白。
