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First-trimester maternal serum 25-hydroxyvitamin D₃ status and pregnancy outcome.早孕期母体血清 25-羟维生素 D₃ 水平与妊娠结局。
Int J Gynaecol Obstet. 2012 Jan;116(1):6-9. doi: 10.1016/j.ijgo.2011.07.029. Epub 2011 Sep 28.
2
Vitamin D status in pregnant Indian women across trimesters and different seasons and its correlation with neonatal serum 25-hydroxyvitamin D levels.印度孕妇在妊娠各期和不同季节的维生素 D 状况及其与新生儿血清 25-羟维生素 D 水平的相关性。
Br J Nutr. 2011 Nov;106(9):1383-9. doi: 10.1017/S000711451100170X. Epub 2011 May 31.
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ACOG Committee Opinion No. 495: Vitamin D: Screening and supplementation during pregnancy.美国妇产科医师学会委员会意见 No.495：维生素 D：妊娠期筛查与补充。
Obstet Gynecol. 2011 Jul;118(1):197-198. doi: 10.1097/AOG.0b013e318227f06b.
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Vitamin D₃ levels in pregnant women and newborns at a private tertiary care hospital in Delhi, India.印度德里一家私立三级护理医院中孕妇和新生儿的维生素D₃水平。
Int J Gynaecol Obstet. 2011 Jun;113(3):240-1. doi: 10.1016/j.ijgo.2011.01.005. Epub 2011 Mar 30.
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Vitamin D deficiency in healthy breastfed term infants at 3 months & their mothers in India: seasonal variation & determinants.印度健康母乳喂养的足月婴儿及其母亲在 3 个月时的维生素 D 缺乏症：季节性变化及决定因素。
Indian J Med Res. 2011 Mar;133(3):267-73.
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A nested case-control study of midgestation vitamin D deficiency and risk of severe preeclampsia.中孕期维生素 D 缺乏与重度子痫前期风险的巢式病例对照研究。
J Clin Endocrinol Metab. 2010 Nov;95(11):5105-9. doi: 10.1210/jc.2010-0996. Epub 2010 Aug 18.
7
Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia.早发型重度子痫前期患者的血浆 25-羟维生素 D 水平。
Am J Obstet Gynecol. 2010 Oct;203(4):366.e1-6. doi: 10.1016/j.ajog.2010.06.036. Epub 2010 Aug 8.
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Current maternal-infant micronutrient status and the effects on birth weight in the United Arab Emirates.当前阿联酋母婴微量营养素状况及其对出生体重的影响。
East Mediterr Health J. 2009 Nov-Dec;15(6):1399-406.
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Maternal early pregnancy vitamin D status in relation to fetal and neonatal growth: results of the multi-ethnic Amsterdam Born Children and their Development cohort.母亲孕早期维生素 D 状况与胎儿和新生儿生长的关系：多民族阿姆斯特丹出生儿童及其发育队列研究结果。
Br J Nutr. 2010 Jul;104(1):108-17. doi: 10.1017/S000711451000022X. Epub 2010 Mar 2.
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Association between vitamin D deficiency and primary cesarean section.维生素D缺乏与初次剖宫产之间的关联。
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印度北部一家三级护理中心关于母亲及其新生儿的维生素D状况及其与妊娠结局的关联的经验

Vitamin D Status in Mothers and Their Newborns and Its Association with Pregnancy Outcomes: Experience from a Tertiary Care Center in Northern India.

作者信息

Arora Saloni, Goel Poonam, Chawla Deepak, Huria Anju, Arya Adhi

机构信息

Department of Obstetrics and Gynaecology, D Block Level IV GMCH Sector 32, Chandigarh, 160031 India.

Department of Pediatrics, D Block Level IV GMCH Sector 32, Chandigarh, 160031 India.

出版信息

J Obstet Gynaecol India. 2018 Oct;68(5):389-393. doi: 10.1007/s13224-017-1067-3. Epub 2017 Nov 7.

DOI:10.1007/s13224-017-1067-3
PMID:30224844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6133794/
Abstract

OBJECTIVE

Study was planned to know vitamin D status in mothers and their newborns and effect of vitamin D deficiency on pregnancy outcome. Study design: Two hundred consecutive pregnant women with singleton pregnancy admitted to the labor ward of a tertiary care center were recruited for the study. Maternal and cord blood samples were taken and analyzed for 25(OH) D level. Maternal and fetal outcomes were studied.

RESULTS

High prevalence of hypovitaminosis D was found among pregnant women. Eighty-six percentage had vitamin D deficiency, 9.5% had insufficiency, and only 4.5% had sufficient vitamin D level. Women with preeclampsia had statistically significant vitamin D deficiency and insufficiency as compared to patients who had normal blood pressure levels ( = 0.04). Cesarean section rate was significantly higher in patients with vitamin D deficiency and insufficiency compared to sufficient group ( = 0.004). Cord blood 25(OH) D levels strongly correlated with maternal serum 25 (OH) D levels ( = 0.001, correlation coefficient  = 0.84).

CONCLUSIONS

This study showed a very high prevalence of hypovitaminosis D among pregnant women and excellent correlation between maternal and fetal 25(OH) D levels. Hypovitaminosis D was associated with preeclampsia, increased Cesarean rate, and low birth weight babies.

摘要

目的

本研究旨在了解母亲及其新生儿的维生素D状况，以及维生素D缺乏对妊娠结局的影响。研究设计：选取200例连续入住三级医疗中心产房的单胎妊娠孕妇作为研究对象。采集母血和脐血样本，分析25(OH)D水平。对母婴结局进行研究。

结果

孕妇中维生素D缺乏症的患病率很高。86%的孕妇维生素D缺乏，9.5%的孕妇维生素D不足，只有4.5%的孕妇维生素D水平充足。与血压正常的患者相比，先兆子痫患者的维生素D缺乏和不足具有统计学意义（P = 0.04）。与维生素D充足组相比，维生素D缺乏和不足的患者剖宫产率显著更高（P = 0.004）。脐血25(OH)D水平与母血血清25(OH)D水平密切相关（P = 0.001，相关系数 = 0.84）。

结论

本研究显示孕妇中维生素D缺乏症的患病率非常高，且母婴25(OH)D水平之间具有良好的相关性。维生素D缺乏与先兆子痫、剖宫产率增加和低体重儿有关。