Chauhan Anahita, Prasad Madhva
Department of Gynecology and Obstetrics, Seth GS Medical College and KEM Hospital, Acharya Donde Marg, Parel, Mumbai, Maharashtra 400012 India.
J Obstet Gynaecol India. 2018 Oct;68(5):394-399. doi: 10.1007/s13224-017-1073-5. Epub 2017 Nov 11.
The objective was to observe the characteristics among pregnant patients with a diagnosed hemoglobinopathy and to study the obstetric and medical morbidity patterns during the antenatal and the perinatal periods in this group of patients.
A prospective observational study was conducted in a tertiary care center.
Sixty patients were studied in 11 months. Primigravidae (43.3%) formed the highest percentage of patients. β Thalassemia trait was the most common hemoglobinopathy, seen in 81.66% of study subjects. The hemoglobin value ranged from 5.7 to 13.0, with an average of 9.2 g/dl. Thyroid problems were the most common associated medical disorder. Though IUGR and placenta previa were common, there were no major obstetric problems. There were 57 live births and 1 fresh stillbirth. Two patients had spontaneous abortion for which uterine curettage was done. LSCS was the most common obstetric outcome. Patients with sickle-cell disease required more blood transfusion than those with beta-thalassemia trait. There were 2 maternal mortalities, and both the patients were the diagnosed cases of sickle-cell disease.
While the perinatal outcomes among women with sickle-cell disease are poor, the outcomes in pregnant patients with beta-thalassemia trait were not a cause of major concern.
观察确诊为血红蛋白病的孕妇的特征，并研究该组患者在产前和围产期的产科及内科发病模式。
在一家三级医疗中心进行了一项前瞻性观察研究。
在11个月内对60例患者进行了研究。初产妇（43.3%）占患者比例最高。β地中海贫血特征是最常见的血红蛋白病，在81.66%的研究对象中可见。血红蛋白值范围为5.7至13.0，平均为9.2g/dl。甲状腺问题是最常见的相关内科疾病。虽然胎儿生长受限和前置胎盘很常见，但没有重大产科问题。有57例活产和1例新鲜死产。2例患者发生自然流产并进行了刮宫术。剖宫产是最常见的产科结局。镰状细胞病患者比β地中海贫血特征患者需要更多输血。有2例孕产妇死亡，且这两名患者均为镰状细胞病确诊病例。
虽然镰状细胞病女性的围产期结局较差，但β地中海贫血特征的孕妇结局并非主要担忧原因。
