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5'-(CGA)序列辅助的超分子DNA纳米结构的pH控制组装

5'-(CGA) sequence-assisted pH-controlled assembly of supramolecular DNA nanostructure.

作者信息

Yan Yuting, Cao Yanwei, Xiao Chunsheng, Li Yang, Xiang Xiaoxuan, Guo Xinhua

机构信息

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, People's Republic of China.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.

出版信息

R Soc Open Sci. 2018 Aug 1;5(8):180123. doi: 10.1098/rsos.180123. eCollection 2018 Aug.

DOI:10.1098/rsos.180123
PMID:30225006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6124056/
Abstract

Herein, the DNA strands containing 5'-(CGA) and consecutive guanines are used to construct supramolecular DNA nanostructures that are size-controlled by pH values. Additionally, the introduction of thymine linkers within DNA nanostructures is necessary to maintain the stability of long-sized nanostructures. This work also demonstrates a method for accurately building DNA nanostructures.

摘要

在此，含有5'-(CGA)和连续鸟嘌呤的DNA链被用于构建超分子DNA纳米结构，其尺寸由pH值控制。此外，在DNA纳米结构中引入胸腺嘧啶连接体对于维持长尺寸纳米结构的稳定性是必要的。这项工作还展示了一种精确构建DNA纳米结构的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f442/6124056/b5d7e0f81b19/rsos180123-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f442/6124056/0153f37dd34b/rsos180123-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f442/6124056/b90efef62f80/rsos180123-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f442/6124056/50c70bb534a6/rsos180123-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f442/6124056/80be71b1e079/rsos180123-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f442/6124056/b5d7e0f81b19/rsos180123-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f442/6124056/0153f37dd34b/rsos180123-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f442/6124056/b90efef62f80/rsos180123-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f442/6124056/50c70bb534a6/rsos180123-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f442/6124056/80be71b1e079/rsos180123-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f442/6124056/b5d7e0f81b19/rsos180123-g5.jpg

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本文引用的文献

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Construction of a junction DNA nanostructure and modulation of the junction switching to quadruplexes.连接体DNA纳米结构的构建及连接体向四链体转换的调控。
R Soc Open Sci. 2017 Dec 20;4(12):171337. doi: 10.1098/rsos.171337. eCollection 2017 Dec.
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Crystalline Dipeptide Nanobelts Based on Solid-Solid Phase Transformation Self-Assembly and Their Polarization Imaging of Cells.基于固-固相变自组装的晶态二肽纳带及其对细胞的偏振成像。
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Self-Assembled Luminescent Quantum Dots To Generate Full-Color and White Circularly Polarized Light.
自组装发光量子点产生全彩色和白色圆偏振光。
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DNA Nanotechnology for Precise Control over Drug Delivery and Gene Therapy.用于精确控制药物递送和基因治疗的DNA纳米技术。
Small. 2016 Mar 2;12(9):1117-32. doi: 10.1002/smll.201502167. Epub 2016 Jan 3.
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Self-assembled G-quadruplex nanostructures: AFM and voltammetric characterization.自组装 G-四链体纳米结构：原子力显微镜和伏安特性表征。
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