连接体DNA纳米结构的构建及连接体向四链体转换的调控。
Construction of a junction DNA nanostructure and modulation of the junction switching to quadruplexes.
作者信息
Cao Yanwei, Xiang Xiaoxuan, Pei Renjun, Li Yang, Yan Yuting, Guo Xinhua
机构信息
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, People's Republic of China.
CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, People's Republic of China.
出版信息
R Soc Open Sci. 2017 Dec 20;4(12):171337. doi: 10.1098/rsos.171337. eCollection 2017 Dec.
A junction DNA nanostructure has been successfully built in lithium acetate buffer solution at a near-neutral pH value through the connection of two slipped junction structures that are formed by G-rich and C-rich strands. The GC-rich duplex junctions in the nanostructure can be switched to G-quadruplexes and i-motifs in weakly acidic potassium acetate solution, which leads to the assembly of DNA nanostructures composed of alternating quadruplex and duplex DNA structures. The transformation between different DNA nanoarchitectures may be applied to the operation of 'DNA nanomachines'.
通过连接由富含G的链和富含C的链形成的两个滑动连接结构，在接近中性pH值的醋酸锂缓冲溶液中成功构建了一种连接DNA纳米结构。纳米结构中富含GC的双链连接在弱酸性醋酸钾溶液中可转变为G-四链体和i-基序，这导致了由交替的四链体和双链DNA结构组成的DNA纳米结构的组装。不同DNA纳米结构之间的转变可能应用于“DNA纳米机器”的操作。
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