结缔组织生长因子在糖尿病视网膜病变纤维化中作用的研究进展
Research progress on the role of connective tissue growth factor in fibrosis of diabetic retinopathy.
作者信息
Ma Teng, Dong Li-Jie, Du Xue-Li, Niu Rui, Hu Bo-Jie
机构信息
Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute, Ophthalmology College of Tianjin Medical University, Tianjin 300384, China.
出版信息
Int J Ophthalmol. 2018 Sep 18;11(9):1550-1554. doi: 10.18240/ijo.2018.09.20. eCollection 2018.
Abstract
Diabetic retinopathy (DR) is one of the most important types of diabetic microangiopathy, which is a specific change of fundus lesions and is one of the most serious complications of diabetes. When DR develops to proliferative DR, the main factors of decreasing vision, and even blindness, include retinal detachment and vitreous hemorrhage caused by contraction of blood vessels by fiber membrane. Recent studies reported that the formation of fiber vascular membrane is closely related to retinal fibrosis. The connective tissue growth factor (CTGF) is a cytokine that is closely related to DR fibrosis. However, its mechanism is poorly understood. This paper summarizes the recent studies about CTGF on DR fibrosis for a comprehensive understanding of the role and mechanism of CTGF in PDR.
摘要
糖尿病视网膜病变（DR）是糖尿病微血管病变最重要的类型之一，是眼底病变的一种特异性改变，也是糖尿病最严重的并发症之一。当DR发展为增殖性DR时，导致视力下降甚至失明的主要因素包括纤维膜收缩血管引起的视网膜脱离和玻璃体出血。最近的研究报道，纤维血管膜的形成与视网膜纤维化密切相关。结缔组织生长因子（CTGF）是一种与DR纤维化密切相关的细胞因子。然而，其机制尚不清楚。本文总结了近年来关于CTGF在DR纤维化方面的研究，以全面了解CTGF在增殖性糖尿病视网膜病变中的作用和机制。
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