心肺适能与代谢综合征风险因素的聚集呈负相关：鲍尔州立大学成人健身项目纵向生活方式研究。
Cardiorespiratory Fitness Is Inversely Associated With Clustering of Metabolic Syndrome Risk Factors: The Ball State Adult Fitness Program Longitudinal Lifestyle Study.
作者信息
Kelley Elizabeth, Imboden Mary T, Harber Matthew P, Finch Holmes, Kaminsky Leonard A, Whaley Mitchell H
机构信息
Clinical Exercise Physiology Program, Human Performance Laboratory, Ball State University, Muncie, IN.
Department of Educational Psychology, Ball State University, Muncie, IN.
出版信息
Mayo Clin Proc Innov Qual Outcomes. 2018 May 8;2(2):155-164. doi: 10.1016/j.mayocpiqo.2018.03.001. eCollection 2018 Jun.
OBJECTIVE
The focus of this study was the association between the metabolic syndrome (MetSyn) and cardiorespiratory fitness (CRF) defined as maximal oxygen uptake (VO). Although previous research has shown a relationship between MetSyn and CRF, most studies are based on measures of CRF and different cardiometabolic risk factor from earlier guidelines.
PARTICIPANTS AND METHODS
The metabolic markers included in the present study were central obesity, elevated plasma triglycerides, elevated fasting high-density lipoprotein cholesterol, impaired fasting plasma glucose, hypertension, or pharmacologic treatment for diagnosed hypertension, hypertriglyceridemia, low high-density lipoprotein cholesterol, or diabetes. A cohort of 3636 adults (1629 women, 2007 men; mean ± SD age, 44.7±12.3 years) completed CRF and metabolic risk factor assessment between January 1, 1971, and November 1, 2016. The CRF was defined as a measured VO from a cardiopulmonary exercise test on a treadmill, with a respiratory exchange ratio value of 1.0 or more.
RESULTS
Prevalence of MetSyn (≥3 factors) was 26% (n=953) in the cohort, with men having a greater likelihood for MetSyn compared with women (<.001). The difference in VO between those individuals with MetSyn and those without was approximately 2.3 (2.0-2.5) metabolic equivalents. Logistic regression analyses showed a significant inverse and graded association between quartiles of CRF and MetSyn for the group overall (<.001), with odds ratios (95% CI) using the lowest fitness group as the referent group of 0.67 (0.55-0.81), 0.41 (0.34-0.51), and 0.10 (0.07-0.14) for VO (<.001). The sex-specific odds ratios were 0.25 (0.18-0.34), 0.05 (0.02-0.10), and 0.02 (0.01-0.09) for women and 0.43 (0.31-0.59), 0.19 (0.14-0.27), and 0.03 (0.02-0.05) for men (<.001).
CONCLUSION
These results with current risk factor thresholds and a large number of women demonstrate that low VO is associated with MetSyn.
目的
本研究重点关注代谢综合征（MetSyn）与以最大摄氧量（VO₂）定义的心肺适能（CRF）之间的关联。尽管先前的研究已表明MetSyn与CRF之间存在关联，但大多数研究基于早期指南中CRF和不同心血管代谢危险因素的测量方法。
参与者与方法
本研究纳入的代谢指标包括中心性肥胖、血浆甘油三酯升高、空腹高密度脂蛋白胆固醇升高、空腹血糖受损、高血压，或针对已确诊的高血压、高甘油三酯血症、低高密度脂蛋白胆固醇或糖尿病进行的药物治疗。一组3636名成年人（1629名女性，2007名男性；平均±标准差年龄为44.7±12.3岁）在1971年1月1日至2016年11月1日期间完成了CRF和代谢危险因素评估。CRF定义为在跑步机上进行心肺运动测试测得的VO₂，呼吸交换率值为1.0或更高。
结果
该队列中MetSyn（≥3项因素）的患病率为26%（n = 953），男性患MetSyn的可能性高于女性（P <.001）。患有MetSyn的个体与未患MetSyn的个体之间VO₂的差异约为2.3（2.0 - 2.5）代谢当量。逻辑回归分析显示，对于总体人群，CRF四分位数与MetSyn之间存在显著的负向分级关联（P <.001），以最低适能组作为参照组，VO₂的比值比（95%置信区间）分别为0.67（0.55 - 0.81）、0.41（0.34 - 0.51）和0.10（0.07 - 0.14）（P <.001）。女性的性别特异性比值比分别为0.25（0.18 - 0.34）、0.05（0.02 - 0.10）和0.02（0.01 - 0.09），男性为0.43（0.31 - 0.59）、0.19（0.14 - 0.27）和0.03（0.02 - 0.05）（P <.001）。
结论
这些基于当前危险因素阈值且包含大量女性的结果表明，低VO₂与MetSyn相关。
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