Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Indian J Dermatol Venereol Leprol. 2019 Jan-Feb;85(1):51-55. doi: 10.4103/ijdvl.IJDVL_861_17.
Normal immune functioning requires sufficient levels of trace elements including zinc and selenium, while elements such as nickel can be immunotoxic.
To assess long-term abnormalities in zinc, selenium and nickel levels in patients with chronic recurrent warts.
Toenail samples were taken from 28 patients with chronic recurrent warts and 30 apparently healthy matching controls were analysed. Toenail concentrations of zinc, selenium and nickel were measured using inductively-coupled plasma-optical emission spectroscopy.
Selenium levels were significantly higher in patients than in controls (P = 0.03). Levels of trace elements did not correlate with the number or duration of warts. Toenail nickel levels in all subjects were higher than globally reported values.
A small sample size and the absence of regional reference ranges for concentrations of trace elements in toenails.
Zinc does not seem to be involved in the chronicity of warts, and it is unclear if selenium has a protective role against warts. Our finding of high concentrations of nickel in both patients and controls raises concerns about environmental exposure.
正常的免疫功能需要充足的微量元素水平，包括锌和硒，而镍等元素则可能具有免疫毒性。
评估慢性复发性疣患者体内锌、硒和镍水平的长期异常情况。
从 28 名慢性复发性疣患者和 30 名看似健康的匹配对照者中采集趾甲样本，并进行分析。采用电感耦合等离子体-光学发射光谱法测量趾甲中的锌、硒和镍浓度。
患者的硒水平明显高于对照组（P = 0.03）。微量元素水平与疣的数量或持续时间无关。所有受试者的趾甲镍水平均高于全球报告的正常值。
样本量小，以及缺乏趾甲中微量元素浓度的区域参考范围。
锌似乎与疣的慢性化无关，而硒是否对疣具有保护作用尚不清楚。我们发现患者和对照组的镍浓度均较高，这引发了对环境暴露的担忧。
