轻度急性胰腺炎患者早期经口进食及快速增加饮食的荟萃分析。
A meta-analysis of early oral refeeding and quickly increased diet for patients with mild acute pancreatitis.
作者信息
Zhang Jiran, Zhu Sha, Tan Dingyu, Ma Aiwen, Yang Yan, Xu Jiyang
机构信息
Department of Emergency, Clinical Medical College of Yangzhou University, Subei People's Hospital, Yangzhou 225001, Jiangsu Province, China.
Department of Operating Room, Clinical Medical College of Yangzhou University, Subei People's Hospital, Yangzhou 225001, Jiangsu Province, China.
出版信息
Saudi J Gastroenterol. 2019 Jan-Feb;25(1):14-19. doi: 10.4103/sjg.SJG_240_18.
BACKGROUND/AIM: The objective of the study is to clarify whether early oral refeeding (EORF) and quickly increasing diet (QID) are of benefit to patients with mild acute pancreatitis compared with a traditional oral refeeding strategy.
MATERIALS AND METHODS
Studies were searched in PubMed, Cochrane library, ScienceDirect, SpringerLink, China Biology Medicine disc and Embase. A meta-analysis was then performed, using relapse of abdominal pain, nausea/vomiting, and length of hospital stay (LOHS) as the evaluation indices.
RESULTS
Eight trials met the inclusion criteria. For the oral refeeding time group, EORF could significantly decrease the LOHS (mean deviation [MD] -1.97; 95% confidence interval (CI) -3.32 to -0.62;P = 0.004), and there was no significant difference for relapse of abdominal pain (relative risk [RR] 1.17; 95% CI 0.69-2.00;P = 0.56) or nausea/vomiting (RR 1.30; 95% CI 0.19-8.82;P = 0.79) when compared with conventional oral refeeding. For the oral refeeding material group, there was no significant difference for relapse of abdominal pain (RR 0.86; 95% CI 0.53-1.40;P = 0.54), nausea/vomiting (risk difference -0.01; 95% CI -0.19-0.18;P = 0.94), or LOHS (MD -0.88; 95% CI -2.24-0.48;P = 0.20) between the QID and stepwise increasing diet groups.
CONCLUSION
Pure EORF or QID caused no damage to patients with mild acute pancreatitis, and EORF could significantly decrease the LOHS.
背景/目的：本研究的目的是阐明与传统的经口进食策略相比，早期经口进食（EORF）和快速增加饮食量（QID）对轻度急性胰腺炎患者是否有益。
材料与方法
在PubMed、Cochrane图书馆、ScienceDirect、SpringerLink、中国生物医学光盘数据库和Embase中检索相关研究。然后进行荟萃分析，将腹痛复发、恶心/呕吐及住院时间（LOHS）作为评估指标。
结果
八项试验符合纳入标准。对于经口进食时间组，与传统经口进食相比，EORF可显著缩短住院时间（平均差值[MD] -1.97；95%置信区间[CI] -3.32至-0.62；P = 0.004），而腹痛复发（相对危险度[RR] 1.17；95% CI 0.69 - 2.00；P = 0.56）或恶心/呕吐（RR 1.30；95% CI 0.19 - 8.82；P = 0.79）方面无显著差异。对于经口进食材料组，QID组与逐步增加饮食量组在腹痛复发（RR 0.86；95% CI 0.53 - 1.40；P = 0.54）、恶心/呕吐（风险差值 -0.01；95% CI -0.19至0.18；P = 0.94）或住院时间（MD -0.88；95% CI -2.24至0.48；P = 0.20）方面均无显著差异。
结论
单纯的EORF或QID对轻度急性胰腺炎患者无损害，且EORF可显著缩短住院时间。
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