Dreifuss F, Farwell J, Holmes G, Joseph C, Lockman L, Madsen J A, Minarcik C J, Rothner A D, Shewmon D A
Arch Neurol. 1986 Nov;43(11):1107-10. doi: 10.1001/archneur.1986.00520110007005.
Fifty-two patients were enrolled in a four-week randomized multicenter study comparing nitrazepam and corticotropin in the treatment of infantile spasms. The drugs' efficacy was evaluated in 48 patients, all less than 2 years of age. Both treatments resulted in a statistically significant reduction in spasm frequency from that at baseline, but the difference between treatments was not significant. The number of patients who experienced side effects was similar in the two treatment groups, but the adverse effects encountered among the patients treated with corticotropin were qualitatively more severe and required the discontinuation of treatment in six patients.
52名患者参与了一项为期四周的随机多中心研究，该研究比较了硝西泮和促肾上腺皮质激素治疗婴儿痉挛症的效果。对48名年龄均小于2岁的患者的药物疗效进行了评估。两种治疗方法均使痉挛频率较基线时有统计学意义的显著降低，但治疗方法之间的差异并不显著。两个治疗组中出现副作用的患者数量相似，但促肾上腺皮质激素治疗的患者中出现的不良反应在性质上更为严重，有6名患者需要停止治疗。
