层层介孔二氧化硅-透明质酸-环糊精双功能“层叠”：荧光探针及主客体相互作用在药物递送领域的应用研究

Layer by Layer Mesoporous Silica-Hyaluronic Acid-Cyclodextrin Bifunctional "Lamination": Study of the Application of Fluorescent Probe and Host⁻Guest Interactions in the Drug Delivery Field.

作者信息

Nie Kun, An Qi, Zink Jeffrey I, Yu Xiang, Zhang Yihe

机构信息

Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences (Beijing), Beijing 100083, China.

Department of Chemistry and Biochemistry and California Nano Systems Institute, University of California, Los Angeles, CA 90095, USA.

出版信息

Materials (Basel). 2018 Sep 17;11(9):1745. doi: 10.3390/ma11091745.

The layer-by-layer technique was exploited to adjust the magnitude of the host⁻guest interactions between adamantane and cyclodextrin. The effect depends on numerous complex and changeable growth profiles of the films and the number of bilayers. These composite films of mesoporous silica nanoparticles and hyaluronic acid⁻cyclodextrin(HA-CD) were constructed to load the fluorescent dyes and peptides. The release rates of these molecules would decrease with an increase in the number of layers. A laser scanning confocal microscope was utilized to obtain the diffusion coefficient of fluorescein isothiocyanate. Hybrid films could be applied to increase the loading of different kinds of molecules and could also be integrated into the lamination to delay the rate of release.