Department of Obstetrics and Gynecology, Washington University in St. Louis, MO, USA.
Department of Biology, Washington University in St. Louis, MO, USA.
Best Pract Res Clin Obstet Gynaecol. 2018 Oct;52:60-67. doi: 10.1016/j.bpobgyn.2018.08.001. Epub 2018 Aug 20.
Circadian rhythms, endogenous and entrainable adaptations to 24-hour cycles of light and dark, influence almost all physiologic functions. Emerging evidence suggests that the disruption of normal circadian rhythms, termed chronodisruption, could affect a wide range of disease-related processes. In this review, we describe the molecular generation of circadian rhythms, the effects of chronodisruption on human health, the circadian timing of birth in multiple species, the possible effects of chronodisruption on preterm birth, and some of the open questions in this field.
昼夜节律，即内源性和可适应的对 24 小时光暗循环的适应，影响几乎所有的生理功能。新出现的证据表明，正常昼夜节律的破坏，称为生物钟紊乱，可能会影响广泛的与疾病相关的过程。在这篇综述中，我们描述了昼夜节律的分子产生，生物钟紊乱对人类健康的影响，多种物种的出生昼夜节律，生物钟紊乱对早产可能产生的影响，以及该领域的一些悬而未决的问题。
