Trovão José Nuno, Serefoglu Ege Can
Department of Psychiatry of Centro Hospitalar Vila Nova de Gaia/Espinho, Porto, Portugal.
Department of Urology, Bahceci Health Group, Istanbul, Turkey.
Int J Impot Res. 2018 Nov;30(6):279-286. doi: 10.1038/s41443-018-0077-8. Epub 2018 Sep 18.
While the pathophysiology of several psychiatric disorders has become modestly elucidated in the last decade, comorbid sexual dysfunctions in such patients are frequently left apart from clinical and research interest. We aimed to address the malfunctioning neurocircuitry underlying sexual dysfunctions in depression, anxiety, schizophrenia and mania. We performed a comprehensive literature review, addressing any combination of the topics of "neurobiology"/"neural", "sexual"/"desire"/"arousal"/"orgasm"/"ejaculation" and "depression"/"anxiety"/"schizophrenia"/"mania"/"bipolar". Altered neurotransmitter levels or connectivity in patients are reported in sexual dysfunctions (either desire, arousal, orgasm and ejaculation) and main psychiatric disorders (depression, anxiety, mania and schizophrenia). Neuronal pathways responsible for the occurrence of sexual dysfunctions in psychiatric disorders can be figured out by overlap of their acknowledged pathophysiology. However, specific research in that group is scant, so future tailored studies are warranted to elucidate actual mechanisms.
尽管在过去十年中，几种精神疾病的病理生理学已得到一定程度的阐明，但这类患者中并存的性功能障碍却常常被排除在临床和研究关注之外。我们旨在探讨抑郁症、焦虑症、精神分裂症和躁狂症中性功能障碍背后的神经回路功能障碍。我们进行了一项全面的文献综述，涉及“神经生物学”/“神经的”、“性”/“欲望”/“唤起”/“性高潮”/“射精”以及“抑郁症”/“焦虑症”/“精神分裂症”/“躁狂症”/“双相情感障碍”等主题的任意组合。性功能障碍（无论是欲望、唤起、性高潮还是射精方面）以及主要精神疾病（抑郁症、焦虑症、躁狂症和精神分裂症）患者均存在神经递质水平或连接性的改变。通过公认的病理生理学重叠，可以找出导致精神疾病中性功能障碍发生的神经元通路。然而，该领域的具体研究较少，因此有必要开展未来针对性的研究以阐明实际机制。
