Michaels R H, Norden C W
J Infect Dis. 1977 Aug;136(2):222-8. doi: 10.1093/infdis/136.2.222.
A longitudinal study of pharyngeal colonization with Haemophilus influenzae type b included 264 members of families that had a child with meningitis or epiglottitis due to this organism. It was found that (1) 52 of 67 such families contained at least one carrier of H. influenzae type b, who was usually a sibling; (2) H. influenzae type b spread slowly in 39 families colonized continuously during a six-month period, with only eight of 19 uncolonized siblings acquiring the organism during that time; (3) 18 of 30 initially colonized families contained one or more carriers after 12 months, including 30% of initially colonized siblings; (4) the highest carrier rate of H. influenzae type b occurred in recovered patients, 80% of whom were colonized after hospital discharge; (5) titers of antibody in serum were higher in colonized than in uncolonized individuals (P less than 0.001); (6) levels of antibody in colonized children were lower in those younger than two years than in older children (P less than 0.001); and (7) prolonged or heavy colonization with H. influenzae type b was not associated with unusually high titers of antibody.
一项关于b型流感嗜血杆菌咽部定植的纵向研究纳入了264个家庭的成员，这些家庭中有儿童因该病原体感染患脑膜炎或会厌炎。研究发现：(1) 67个此类家庭中有52个家庭至少有一名b型流感嗜血杆菌携带者，通常是兄弟姐妹；(2) 在6个月期间持续定植的39个家庭中，b型流感嗜血杆菌传播缓慢，19名未定植的兄弟姐妹中只有8名在此期间感染了该病原体；(3) 30个最初定植的家庭中有18个在12个月后有一名或多名携带者，包括30%最初定植的兄弟姐妹；(4) b型流感嗜血杆菌的最高携带率出现在康复患者中，其中80%在出院后被定植；(5) 定植个体血清中的抗体滴度高于未定植个体（P<0.001）；(6) 定植儿童中，两岁以下儿童的抗体水平低于大龄儿童（P<0.001）；(7) b型流感嗜血杆菌的长期或大量定植与异常高的抗体滴度无关。
