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本文引用的文献

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VARIATION AND TYPE SPECIFICITY IN THE BACTERIAL SPECIES HEMOPHILUS INFLUENZAE.流感嗜血杆菌的细菌种属变异性和类型特异性。
J Exp Med. 1931 Mar 31;53(4):471-92. doi: 10.1084/jem.53.4.471.
2
An improved antiserum agar method for detecting carriage of Haemophilus influenzae type b.一种用于检测b型流感嗜血杆菌携带情况的改良抗血清琼脂方法。
Eur J Clin Microbiol Infect Dis. 1993 Mar;12(3):215-7. doi: 10.1007/BF01967116.
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Antibody persistence after accelerated immunisation against Haemophilus influenzae type b.b型流感嗜血杆菌加速免疫后的抗体持久性
BMJ. 1993 Apr 10;306(6883):971-2. doi: 10.1136/bmj.306.6883.971.
4
Decreased Haemophilus colonization in children vaccinated with Haemophilus influenzae type b conjugate vaccine.接种b型流感嗜血杆菌结合疫苗的儿童中流感嗜血杆菌定植减少。
J Pediatr. 1993 Apr;122(4):517-23. doi: 10.1016/s0022-3476(05)83529-2.
5
Anti-capsular polysaccharide antibodies reduce nasopharyngeal colonization by Haemophilus influenzae type b in infant rats.抗荚膜多糖抗体可减少b型流感嗜血杆菌在幼鼠鼻咽部的定植。
J Infect Dis. 1993 Feb;167(2):365-71. doi: 10.1093/infdis/167.2.365.
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Declining incidence of Haemophilus influenzae type b disease since introduction of vaccination.自接种疫苗以来，b型流感嗜血杆菌疾病发病率下降。
JAMA. 1993 Jan 13;269(2):246-8.
7
Vaccination with Haemophilus influenzae type b meningococcal protein conjugate vaccine reduces oropharyngeal carriage of Haemophilus influenzae type b among American Indian children.接种b型流感嗜血杆菌脑膜炎球菌结合疫苗可减少美国印第安儿童口腔中b型流感嗜血杆菌的携带。
Pediatr Infect Dis J. 1993 Jul;12(7):593-9. doi: 10.1097/00006454-199307000-00010.
8
Carriage of Haemophilus influenzae type b in children after widespread vaccination with conjugate Haemophilus influenzae type b vaccines.广泛接种b型流感嗜血杆菌结合疫苗后儿童b型流感嗜血杆菌的携带情况
Pediatr Infect Dis J. 1993 Jul;12(7):589-93. doi: 10.1097/00006454-199307000-00009.
9
Haemophilus influenzae type b carriage and immunity four years after receiving the Haemophilus influenzae oligosaccharide-CRM197 (HbOC) conjugate vaccine.接种b型流感嗜血杆菌寡糖-CRM197（HbOC）结合疫苗四年后的b型流感嗜血杆菌携带情况与免疫状况
Pediatr Infect Dis J. 1993 Jun;12(6):478-84. doi: 10.1097/00006454-199306000-00005.
10
Quantitative bacterial culture from adenoid lymphatic tissue with special reference to Haemophilus [corrected].腺样体淋巴组织的定量细菌培养，特别提及嗜血杆菌属[已校正]。
Acta Otolaryngol. 1993 Sep;113(5):668-72. doi: 10.3109/00016489309135882.

结合疫苗与b型流感嗜血杆菌携带情况

Conjugate vaccines and the carriage of Haemophilus influenzae type b.

作者信息

Barbour M L

机构信息

John Radcliff Hospital, Oxford, England.

出版信息

Emerg Infect Dis. 1996 Jul-Sep;2(3):176-82. doi: 10.3201/eid0203.960303.

DOI:10.3201/eid0203.960303
PMID:8903227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2626802/
Abstract

Pharyngeal carriage of Haemophilus influenzae type b (Hib) is important in the transmission of Hib organisms, the pathogenesis of Hib disease, and the development of immunity to the bacterium. The remarkable success of current vaccination programs against Hib has been due in part to the effect of conjugate Hib vaccines in decreasing carriage of Hib. This review explores evidence for this effect, and discusses the possible mechanisms of the mucosal influence of Hib conjugate vaccines.

摘要

b型流感嗜血杆菌（Hib）的咽部携带在Hib病原体传播、Hib疾病发病机制以及对该细菌免疫的发展中具有重要意义。当前针对Hib的疫苗接种计划取得显著成功，部分原因在于结合型Hib疫苗在降低Hib携带方面的作用。本综述探讨了这一作用的证据，并讨论了Hib结合疫苗产生黏膜影响的可能机制。