BACKGROUND: A dramatic increase in the use of natural products and herbal medicines has been observed globally. Simultaneously, there has been an increase in safety concerns regarding the extensive use of these herbal remedies among health care practitioners. The urban and rural populations of Saudi Arabia still rely on traditional Arabic herbal medicines for the treatment of various diseases. OBJECTIVES: This study aimed to evaluate community pharmacists' knowledge, attitudes, and practices of herbal medicines in the Asir region, Saudi Arabia. METHODS: An online cross-sectional study was conducted among 233 community pharmacists using a structured questionnaire. RESULTS: Pharmacists showed considerable knowledge of the indications of herbal products, with an average score of 84% correct answers, total value < 0.05 and < 0.001. They were also knowledgeable about contraindications, side effects, and interactions, with an average score of 75% correct answers, total value < 0.05 and < 0.001. Community pharmacists had a positive attitude towards herbal products, as 71% of them "agreed" or "strongly agreed" that herbal products were efficacious and 77% of them "agreed" or "strongly agreed" that those products should be sold only in a pharmacy. Herbal products were "often" or "always" dispensed by 67.3% of pharmacists in a pharmacy. CONCLUSION: Pharmacists generally exhibited good knowledge, a positive attitude, and effective practice towards herbal products. However, continuing education programs are needed to train pharmacists in providing client counseling on herbal medicine usage and dispensing them.