Seghaye R, Deflandre E, Remacle-Volon G, Damas J
C R Seances Soc Biol Fil. 1986;180(3):379-85.
In rats, ACTH reduced the oedemas induced by zymosan and lambda carrageenan. ACTH reduced the volume of the exudate induced by sponge implantation and its content in proteins, beta-galactosidase, beta-glucuronidase and PGE2. The inhibitory effect of ACTH was suppressed by adrenalectomy which increased the carrageenan-oedema. The inhibitory effect of ACTH was also suppressed by 17 alpha-methyltestosterone. Corticosterone reduced carrageenan-oedema. The inhibitory effect of corticosterone was suppressed by cycloheximide and actinomycin D. These results suggest that rat adrenal steroids, among which corticosterone, can modulate the reactivity of the animal towards irritating processes. The anti-inflammatory effect of rat adrenal steroids would depend on the formation of lipocortin-like peptides.
在大鼠中，促肾上腺皮质激素（ACTH）可减轻酵母聚糖和λ-角叉菜胶诱导的水肿。ACTH可减少海绵植入诱导的渗出液体积及其蛋白质、β-半乳糖苷酶、β-葡萄糖醛酸酶和前列腺素E2的含量。肾上腺切除术可抑制ACTH的抑制作用，这会增加角叉菜胶诱导的水肿。17α-甲基睾酮也可抑制ACTH的抑制作用。皮质酮可减轻角叉菜胶诱导的水肿。环己酰亚胺和放线菌素D可抑制皮质酮的抑制作用。这些结果表明，大鼠肾上腺类固醇（其中包括皮质酮）可调节动物对刺激过程的反应性。大鼠肾上腺类固醇的抗炎作用将取决于脂皮质素样肽的形成。
