Molnár I, Budavári I, Nánási A, Gyires K, Ikrényi K
Int J Tissue React. 1985;7(6):463-8.
The effects of native and oxidized forms of the new antioxidant drug MTDQ-DS (HUMAN, Hungary) on some parameters of acute inflammatory processes were studied. In short-term in vitro experiments, both forms at 10(-4) to 10(-6) g/l inhibited dose-dependently the zymosan-induced chemotaxis of the rat peritoneal polymorphonuclear (PMN) granulocytes. In short-term in vivo experiments both forms administered intraperitoneally at 450 or 600 mg/kg inhibited the formation of carrageenin oedema in the rat paw. The long-term administration for 3 weeks of native and oxidized MTDQ-DS in doses of 450 mg/kg significantly inhibited the carrageenin-induced oedema formation, the zymosan-induced chemotaxis, and the luminol-dependent light production of rat peritoneal PMN granulocytes. The results suggest that the native and oxidized forms of MTDQ-DS have an antiinflammatory effect since they inhibit several events in the local inflammatory reaction.
研究了新型抗氧化药物MTDQ-DS（匈牙利人用）的天然形式和氧化形式对急性炎症过程某些参数的影响。在短期体外实验中，浓度为10(-4)至10(-6) g/l的两种形式均剂量依赖性地抑制了酵母聚糖诱导的大鼠腹腔多形核（PMN）粒细胞趋化作用。在短期体内实验中，以450或600 mg/kg腹腔注射的两种形式均抑制了大鼠爪中角叉菜胶性水肿的形成。以450 mg/kg剂量对天然和氧化形式的MTDQ-DS进行为期3周的长期给药，可显著抑制角叉菜胶诱导的水肿形成、酵母聚糖诱导的趋化作用以及大鼠腹腔PMN粒细胞的鲁米诺依赖性发光。结果表明，MTDQ-DS的天然形式和氧化形式具有抗炎作用，因为它们抑制了局部炎症反应中的多个事件。
