State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China.
Chem Commun (Camb). 2018 Oct 16;54(83):11717-11720. doi: 10.1039/c8cc06576d.
Two PtIV-artesunate anticancer prodrugs that target RAD51, a crucial protein in homologous recombination mediating the sensitivity of cancer cells to DNA-damaging agents, were designed; their cytotoxicities against BRCA-proficient ovarian and breast cancer cells are significantly higher than those of cisplatin.
设计了两种针对 RAD51 的 PtIV-青蒿琥酯抗癌前药，RAD51 是同源重组过程中的关键蛋白，介导了癌细胞对 DNA 损伤剂的敏感性，它们对 BRCA 功能正常的卵巢癌和乳腺癌细胞的细胞毒性明显高于顺铂。
