Gorkem Umit, Inal Zeynep Ozturk, Inal Hasan Ali, Bostanci Mehmet Omar
Konya Education and Research Hospital, Konya, Turkey.
Endokrynol Pol. 2018;69(6):661-666. doi: 10.5603/EP.a2018.0044. Epub 2018 Sep 19.
The aim of the present study was to investigate the changes in serum progranulin and sex hormone levels in infertile women with obesity.
A total of 171 infertile women who had fertility desire were included in this cross-sectional study. The initial assessment included measurements of weight, height, waist circumference, and hip circumference to calculate body mass index (BMI) and waist/hip ratio. All participants were categorised into two groups in accordance with BMI as a control group ( < 30 kg/m², n = 135) and a study group (≥ 30 kg/m², n = 36). After anthropometric measurements, venous blood samples were taken for analyses of oestradiol and follicle stimulating hormone (FSH), luteinising hormone, total testosterone (TT), 17-hydroxyprogesterone, dehydroepiandrosterone sulphate, anti-Müllerian hormone, and progranulin.
The present study demonstrated that the overweight women had higher FSH levels (p < 0.01). Elevated TT levels were detected in obese women (p < 0.05). Progranulin concentrations were higher in the study group than in the control group (p < 0.05). Regression analysis demonstrated that there was a relationship between the serum progranulin concentrations and BMI (p < 0.05).
Our findings support that the elevated progranulin levels are associated with obesity in infertile women. Therefore, infertile and obese patients may benefit if their serum progranulin levels decrease. Further studies are needed to elucidate this issue.
本研究的目的是调查肥胖不孕女性血清前颗粒蛋白和性激素水平的变化。
本横断面研究共纳入171名有生育意愿的不孕女性。初始评估包括测量体重、身高、腰围和臀围，以计算体重指数（BMI）和腰臀比。所有参与者根据BMI分为两组，对照组（<30kg/m²，n=135）和研究组（≥30kg/m²，n=36）。人体测量后，采集静脉血样本分析雌二醇、促卵泡生成素（FSH）、黄体生成素、总睾酮（TT）、17-羟孕酮、硫酸脱氢表雄酮、抗苗勒管激素和前颗粒蛋白。
本研究表明超重女性的FSH水平较高（p<0.01）。肥胖女性检测到TT水平升高（p<0.05）。研究组的前颗粒蛋白浓度高于对照组（p<0.05）。回归分析表明血清前颗粒蛋白浓度与BMI之间存在关联（p<0.05）。
我们的研究结果支持不孕女性中前颗粒蛋白水平升高与肥胖有关。因此，如果不孕肥胖患者的血清前颗粒蛋白水平降低，可能会受益。需要进一步研究来阐明这个问题。
