Gorkem Umit, Kan Ozgur, Bostanci Mehmet Omer, Taskiran Deniz, Inal Hasan Ali
Hitit University, Medical Faculty, Department of Obstetric and Gynecology, Corum, Turkey.
Hitit University Medical Faculty, Departmant of Obstetric and Gynecology, Corum, Turkey.
Medeni Med J. 2021;36(2):98-105. doi: 10.5222/MMJ.2021.32549. Epub 2021 Jun 18.
Spontaneous abortion is the most common complication of early pregnancy, affecting up to 20% of recognized pregnancies. Kisspeptin is predominantly released by placental syncytiotrophoblasts, and regulates their placental invasion into the uterine matrices. We aimed to establish an association of serum kisspeptin levels with pregnancy outcomes during the early gestational stage of the first trimester.
In this prospective study, 90 pregnant women in their 7 to 8 6/7 gestational weeks were classified into three groups: (i) The control group, consisting of healthy pregnant women (n=30), (ii) the threatened abortion group (n=30), and (iii) the spontaneous abortion group (n=30). The maternal serum samples were analyzed for complete blood count parameters and kisspeptin levels.
There was no statistical difference regarding body mass index (BMI) and gestational age (p=0.370). Regarding detailed obstetric notations, including gravida, parity, abortion, and living children, socioeconomic levels, and employment rates, all study groups were comparable (p>0.05, for all). No significant association was found regarding the biochemical parameters of complete blood count, including neutrophil, lymphocyte, and platelet concentrations, as well as neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratios (PLR) (p>0.05, for all). The median serum kisspeptin levels of the study groups did not differ between the groups (p=0.153). Correlation analysis revealed no significant relationship between serum kisspeptin levels and other study parameters in any study groups (p>0.05, for all).
We found no statistically significant relationship between serum kisspeptin concentrations and pregnancy outcomes in the early gestational stage of the first trimester, and serum kisspeptin concentrations did not seem to be a reliable marker to distinguish abortion status from viable pregnancy.
自然流产是早期妊娠最常见的并发症，影响高达20%的已确认妊娠。 kisspeptin主要由胎盘合体滋养层细胞释放，并调节其向子宫基质的胎盘侵入。我们旨在建立孕早期血清kisspeptin水平与妊娠结局之间的关联。
在这项前瞻性研究中，90名妊娠7至8 6/7周的孕妇被分为三组：（i）对照组，由健康孕妇组成（n = 30），（ii）先兆流产组（n = 30），以及（iii）自然流产组（n = 30）。对孕妇血清样本进行全血细胞计数参数和kisspeptin水平分析。
体重指数（BMI）和孕周方面无统计学差异（p = 0.370）。关于详细的产科记录，包括孕次、产次、流产史、存活子女数、社会经济水平和就业率，所有研究组均具有可比性（所有p>0.05）。全血细胞计数的生化参数，包括中性粒细胞、淋巴细胞和血小板浓度，以及中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR），均未发现显著关联（所有p>0.05）。研究组的血清kisspeptin水平中位数在组间无差异（p = 0.153）。相关性分析显示，任何研究组中血清kisspeptin水平与其他研究参数之间均无显著关系（所有p>0.05）。
我们发现在孕早期血清kisspeptin浓度与妊娠结局之间无统计学显著关系，并且血清kisspeptin浓度似乎不是区分流产状态与活胎妊娠的可靠标志物。
